Clinical Features and Outcomes of Patients With Malignancy and Takotsubo Syndrome: Observations From the International Takotsubo Registry

dc.contributor.authorVictoria L. Cammann
dc.contributor.authorAnnahita Sarcon
dc.contributor.authorKatharina J. Ding
dc.contributor.authorBurkhardt Seifert
dc.contributor.authorKen Kato
dc.contributor.authorDavide Di Vece
dc.contributor.authorKonrad A. zawan
dc.contributor.authorSebastiano Gili
dc.contributor.authorStjepan Jurisic
dc.contributor.authorBeatrice Bacchi
dc.contributor.authorJozef Micek
dc.contributor.authorAntonio H. Frangieh
dc.contributor.authorL. Christian Napp
dc.contributor.authorMilosz Jaguszewski
dc.contributor.authorEduardo Bossone
dc.contributor.authorRodolfo Citro
dc.contributor.authorFabrizio D'Ascenzo
dc.contributor.authorJennifer Franke
dc.contributor.authorMichel Noutsias
dc.contributor.authorMaike Knorr
dc.contributor.authorSusanne Heiner
dc.contributor.authorChristof Burgdorf
dc.contributor.authorWolfgang Koenig
dc.contributor.authorHolger Thiele
dc.contributor.authorCarsten Tschöpe
dc.contributor.authorLawrence Rajan
dc.contributor.authorGuido ichels
dc.contributor.authorRoman Pfister
dc.contributor.authorAlessandro Cuneo
dc.contributor.authorClaudius Jacobshagen
dc.contributor.authorMahir Karakas
dc.contributor.authorAdrian Banning
dc.contributor.authorFlorim Cuculi
dc.contributor.authorRichard Kobza
dc.contributor.authorThomas A. Fischer
dc.contributor.authorTuija Vasankari
dc.contributor.authorK. E. Juhani Airaksinen
dc.contributor.authorRafal Dworakowski
dc.contributor.authorChristoph Kaiser
dc.contributor.authorStefan Osswald
dc.contributor.authorLeonarda Galiuto
dc.contributor.authorWolfgang Dichtl
dc.contributor.authorClément Delmas
dc.contributor.authorOlivier Lairez
dc.contributor.authorJohn D. Horowitz
dc.contributor.authorMartin Kozel
dc.contributor.authorPetr Widimský
dc.contributor.authorPetr Tousek
dc.contributor.authorDavid E. Winchester
dc.contributor.authorEkaterina Gilyarova
dc.contributor.authorAlexandra Shilova
dc.contributor.authorMikhail Gilyarov
dc.contributor.authorIbrahim El‐Battrawy
dc.contributor.authorIbrahim Akin
dc.contributor.authorChristian Ukena
dc.contributor.authorJohann Bauersachs
dc.contributor.authorBurkert M. Pieske
dc.contributor.authorGerd Hasenfuß
dc.contributor.authorWolfgang Rottbauer
dc.contributor.authorRuediger C. Braun‐Dullaeus
dc.contributor.authorGrzegorz Opolski
dc.contributor.authorPhilip MacCarthy
dc.contributor.authorStephan B. Felix
dc.contributor.authorMartin Borggrefe
dc.contributor.authorCarlo Di Mario
dc.contributor.authorFilippo Crea
dc.contributor.authorHugo A. Katus
dc.contributor.authorHeribert Schunkert
dc.contributor.authorThomas Münzel
dc.contributor.authorMichael Böhm
dc.contributor.authorJeroen J. Bax
dc.contributor.authorAbhiram Prasad
dc.contributor.authorJerold Shinbane
dc.contributor.authorThomas F. Lüscher
dc.contributor.authorFrank Ruschitzka
dc.contributor.authorJelena R. Ghadri
dc.contributor.authorand Christian Templin
dc.contributor.organizationfi=sisätautioppi|en=Internal Medicine|
dc.contributor.organizationfi=tyks, vsshp|en=tyks, varha|
dc.contributor.organization-code1.2.246.10.2458963.20.40502528769
dc.converis.publication-id42533864
dc.converis.urlhttps://research.utu.fi/converis/portal/Publication/42533864
dc.date.accessioned2022-10-27T11:49:22Z
dc.date.available2022-10-27T11:49:22Z
dc.description.abstract<h3>Background</h3><p>Clinical characteristics and outcomes of takotsubo syndrome (TTS) patients with malignancy have not been fully elucidated. This study sought to explore differences in clinical characteristics and to investigate short‐ and long‐term outcomes in TTS patients with or without malignancy.</p><h3>Methods and Results</h3><p>TTS patients were enrolled from the International Takotsubo Registry. The TTS cohort was divided into patients with and without malignancy to investigate differences in clinical characteristics and to assess short‐ and long‐term mortality. A subanalysis was performed comparing long‐term mortality between a subset of TTS patients with or without malignancy and acute coronary syndrome (ACS) patients with or without malignancy. Malignancy was observed in 16.6% of 1604 TTS patients. Patients with malignancy were older and more likely to have physical triggers, but less likely to have emotional triggers compared with those without malignancy. Long‐term mortality was higher in patients with malignancy (<i>P</i><0.001), while short‐term outcome was comparable (<i>P</i>=0.17). In a subanalysis, long‐term mortality was comparable between TTS patients with malignancies and ACS patients with malignancies (<i>P</i>=0.13). Malignancy emerged as an independent predictor of long‐term mortality.</p><h3>Conclusions</h3><p>A substantial number of TTS patients show an association with malignancy. History of malignancy might increase the risk for TTS, and therefore, appropriate screening for malignancy should be considered in these patients.</p>
dc.identifier.eissn2047-9980
dc.identifier.jour-issn2047-9980
dc.identifier.olddbid172093
dc.identifier.oldhandle10024/155187
dc.identifier.urihttps://www.utupub.fi/handle/11111/29742
dc.identifier.urnURN:NBN:fi-fe2021042821223
dc.language.isoen
dc.okm.affiliatedauthorAiraksinen, Juhani
dc.okm.affiliatedauthorDataimport, tyks, vsshp
dc.okm.discipline217 Medical engineeringen_GB
dc.okm.discipline3121 Internal medicineen_GB
dc.okm.discipline217 Lääketieteen tekniikkafi_FI
dc.okm.discipline3121 Sisätauditfi_FI
dc.okm.internationalcopublicationinternational co-publication
dc.okm.internationalityInternational publication
dc.okm.typeA1 ScientificArticle
dc.publisherAmerican Heart Association
dc.publisher.countrySwitzerlanden_GB
dc.publisher.countrySveitsifi_FI
dc.publisher.country-codeCH
dc.relation.doi10.1161/JAHA.118.010881
dc.relation.ispartofjournalJournal of the American Heart Association
dc.relation.issue15
dc.relation.volume8
dc.source.identifierhttps://www.utupub.fi/handle/10024/155187
dc.titleClinical Features and Outcomes of Patients With Malignancy and Takotsubo Syndrome: Observations From the International Takotsubo Registry
dc.year.issued2019

Tiedostot

Näytetään 1 - 1 / 1
Ladataan...
Name:
JAHA.118.010881-1.pdf
Size:
1.19 MB
Format:
Adobe Portable Document Format
Description:
Publisher's version