Quantitative Analysis of the Erythrocyte Membrane Proteins in Polycythemia Vera Patients on Treated with Hydroxycarbamide

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dc.contributor.authorKottahachchi D
dc.contributor.authorGooneratne L
dc.contributor.authorJayasekera A
dc.contributor.authorMuth-Pawlak D
dc.contributor.authorMoulder R
dc.contributor.authorImanishi S
dc.contributor.authorAriyaratne A
dc.contributor.authorRokka A
dc.contributor.authorCorthals G
dc.contributor.author
dc.contributor.organizationfi=Turun biotiedekeskus|en=Turku Bioscience Centre|
dc.contributor.organization-code1.2.246.10.2458963.20.18586209670
dc.contributor.organization-code2609201
dc.contributor.organization-code2609240
dc.converis.publication-id2835114
dc.converis.urlhttps://research.utu.fi/converis/portal/Publication/2835114
dc.date.accessioned2025-08-27T22:47:30Z
dc.date.available2025-08-27T22:47:30Z
dc.description.abstract<p> More than 90% of polycythemia vera (PV) patients have a mutation in the protein JAK2,which is closely associated with the erythrocyte membrane. With the comparison of 1-D gelsof erythrocyte membranes obtained from PV patients treated with hydroxycarbamide andthose of untreated controls we observed significant differences in the region of 40&ndash;55 kDa.On the basis of the LC&ndash;MS/MS analysis of this region we report up-regulation of four proteindisulfide isomerases, which was subsequently confirmed by targeted mass spectrometricanalysis. In further studies it will be prudent to compare this in patients both treated andnot treated with hydroxycarbamide.</p>
dc.format.pagerange43
dc.format.pagerange53
dc.identifier.jour-issn2212-9685
dc.identifier.olddbid202808
dc.identifier.oldhandle10024/185835
dc.identifier.urihttps://www.utupub.fi/handle/11111/48853
dc.identifier.urlhttp://www.sciencedirect.com/science/article/pii/S2212968515000100
dc.identifier.urnURN:NBN:fi-fe2021042714852
dc.okm.affiliatedauthorMuth-Pawlak, Dorota
dc.okm.affiliatedauthorImanishi, Susumu
dc.okm.affiliatedauthorMoulder, Robert
dc.okm.affiliatedauthorCorthals, Garry
dc.okm.affiliatedauthorRokka, Anne
dc.okm.discipline1182 Biochemistry, cell and molecular biologyen_GB
dc.okm.discipline3111 Biomedicineen_GB
dc.okm.discipline3141 Health care scienceen_GB
dc.okm.discipline318 Medical biotechnologyen_GB
dc.okm.discipline1182 Biokemia, solu- ja molekyylibiologiafi_FI
dc.okm.discipline3111 Biolääketieteetfi_FI
dc.okm.discipline3141 Terveystiedefi_FI
dc.okm.discipline318 Lääketieteen bioteknologiafi_FI
dc.okm.internationalcopublicationinternational co-publication
dc.okm.internationalityInternational publication
dc.okm.typeA1 ScientificArticle
dc.publisherElsevier
dc.relation.articlenumberS2212968515000100
dc.relation.doi10.1016/j.euprot.2015.04.001
dc.relation.ispartofjournalEuPA open proteomics
dc.relation.issueJune
dc.relation.volume7
dc.source.identifierhttps://www.utupub.fi/handle/10024/185835
dc.titleQuantitative Analysis of the Erythrocyte Membrane Proteins in Polycythemia Vera Patients on Treated with Hydroxycarbamide
dc.year.issued2015

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