A perspective on muscle phenotyping in musculoskeletal research

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dc.contributor.authorFoessl, Ines
dc.contributor.authorAckert-Bicknell, Cheryl L
dc.contributor.authorKague, Erika
dc.contributor.authorLaskou, Faidra
dc.contributor.authorJakob, Franz
dc.contributor.authorKarasik, David
dc.contributor.authorObermayer-Pietsch, Barbara
dc.contributor.authorCo-authors
dc.contributor.authorAlonso, Nerea
dc.contributor.authorBjørnerem, Åshild
dc.contributor.authorBrandi, Maria Luisa
dc.contributor.authorBusse, Björn
dc.contributor.authorCalado, Ângelo
dc.contributor.authorCebi, Alper Han
dc.contributor.authorChristou, Maria
dc.contributor.authorCurran, Kathleen M.
dc.contributor.authorHald, Jannie Dahl
dc.contributor.authorSemeraro, Maria Donatella
dc.contributor.authorDouni, Eleni
dc.contributor.authorDuncan, Emma L.
dc.contributor.authorDuran, Ivan
dc.contributor.authorFormosa, Melissa M.
dc.contributor.authorGabet, Yankel
dc.contributor.authorGhatan, Samuel
dc.contributor.authorGkitakou, Artemis
dc.contributor.authorHassler, Eva Maria
dc.contributor.authorHögler, Wolfgang
dc.contributor.authorHeino, Terhi J.
dc.contributor.authorHendrickx, Gretl
dc.contributor.authorKhashayar, Patricia
dc.contributor.authorKiel, Douglas P.
dc.contributor.authorKoromani, Fjorda
dc.contributor.authorLangdahl, Bente
dc.contributor.authorLopes, Philippe
dc.contributor.authorMäkitie, Outi
dc.contributor.authorMaurizi, Antonio
dc.contributor.authorMedina-Gomez, Carolina
dc.contributor.authorNtzani, Evangelia
dc.contributor.authorOhlsson, Claes
dc.contributor.authorPrijatelj, Vid
dc.contributor.authorRabionet, Raquel
dc.contributor.authorReppe, Sjur
dc.contributor.authorRivadeneira, Fernando
dc.contributor.authorRoshchupkin, Gennady
dc.contributor.authorSharma, Neha
dc.contributor.authorSøe, Kent
dc.contributor.authorStyrkarsdottir, Unnur
dc.contributor.authorSzulc, Pavel
dc.contributor.authorTeti, Anna
dc.contributor.authorTobias, Jon
dc.contributor.authorValjevac, Amina
dc.contributor.authorvan de Peppel
dc.contributor.authorJeroen
dc.contributor.authorvan der Eerden
dc.contributor.authorBram
dc.contributor.authorvan Rietbergen, Bert
dc.contributor.authorZekic, Tatjana
dc.contributor.authorZillikens, M. Carola
dc.contributor.organizationfi=biolääketieteen laitos|en=Institute of Biomedicine|
dc.contributor.organization-code1.2.246.10.2458963.20.77952289591
dc.converis.publication-id456837733
dc.converis.urlhttps://research.utu.fi/converis/portal/Publication/456837733
dc.date.accessioned2025-08-28T01:59:48Z
dc.date.available2025-08-28T01:59:48Z
dc.description.abstract<p>Musculoskeletal research should synergistically investigate bone and muscle to inform approaches for maintaining mobility and to avoid bone fractures. The relationship between sarcopenia and osteoporosis, integrated in the term 'osteosarcopenia', is underscored by the close association shown between these two conditions in many studies, whereby one entity emerges as a predictor of the other. In a recent workshop of Working Group (WG) 2 of the EU Cooperation in Science and Technology (COST) Action 'Genomics of MusculoSkeletal traits Translational Network' (GEMSTONE) consortium (CA18139), muscle characterization was highlighted as being important, but currently under-recognized in the musculoskeletal field. Here, we summarize the opinions of the Consortium and research questions around translational and clinical musculoskeletal research, discussing muscle phenotyping in human experimental research and in two animal models: zebrafish and mouse.<br></p>
dc.format.pagerange478
dc.format.pagerange489
dc.identifier.jour-issn1043-2760
dc.identifier.olddbid208409
dc.identifier.oldhandle10024/191436
dc.identifier.urihttps://www.utupub.fi/handle/11111/57840
dc.identifier.urlhttps://www.sciencedirect.com/science/article/pii/S1043276024000183?via%3Dihub#s0075
dc.identifier.urnURN:NBN:fi-fe2025082787970
dc.language.isoen
dc.okm.affiliatedauthorHeino, Terhi
dc.okm.discipline3111 Biomedicineen_GB
dc.okm.discipline3111 Biolääketieteetfi_FI
dc.okm.internationalcopublicationinternational co-publication
dc.okm.internationalityInternational publication
dc.okm.typeA2 Scientific Article
dc.publisher.countryUnited Statesen_GB
dc.publisher.countryYhdysvallat (USA)fi_FI
dc.publisher.country-codeUS
dc.relation.doi10.1016/j.tem.2024.01.004
dc.relation.ispartofjournalTrends in Endocrinology and Metabolism
dc.relation.issue6
dc.relation.volume35
dc.source.identifierhttps://www.utupub.fi/handle/10024/191436
dc.titleA perspective on muscle phenotyping in musculoskeletal research
dc.year.issued2024

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