Decorin-mediated oncosuppression – a potential future adjuvant therapy for human epithelial cancers

Tietueen suppeat tiedot
dc.contributor.authorAnnele Orvokki Sainio
dc.contributor.authorHannu Tapio Järveläinen
dc.contributor.organizationfi=kliininen laitos|en=Department of Clinical Medicine|
dc.contributor.organization-code1.2.246.10.2458963.20.61334543354
dc.contributor.organization-code2607300
dc.converis.publication-id31133576
dc.converis.urlhttps://research.utu.fi/converis/portal/Publication/31133576
dc.date.accessioned2022-10-27T12:11:45Z
dc.date.available2022-10-27T12:11:45Z
dc.description.abstract<p> </p><p>Currently, the multifaceted role of the extracellular matrix (ECM) in tumorigenesis has been realized. One ECM macromolecule exhibiting potent oncosuppressive actions in tumorigenesis is decorin, the prototype of the small leucine-rich proteoglycan gene family. The actions of decorin include its capability to function as an endogenous pan-receptor tyrosine kinase inhibitor, a regulator of both autophagy and mitophagy, as well as a modulator of the immune system. In this review, we will discuss these topics in more detail. We will also give a summary of preclinical studies exploring the value of decorin-mediated oncosuppression as a potential future adjuvant therapy for epithelial cancers.   </p>
dc.format.pagerange15
dc.format.pagerange5
dc.identifier.eissn1476-5381
dc.identifier.jour-issn0007-1188
dc.identifier.olddbid173831
dc.identifier.oldhandle10024/156925
dc.identifier.urihttps://www.utupub.fi/handle/11111/33083
dc.identifier.urlhttps://bpspubs.onlinelibrary.wiley.com/doi/abs/10.1111/bph.14180
dc.identifier.urnURN:NBN:fi-fe2021042719122
dc.language.isoen
dc.okm.affiliatedauthorSainio, Annele
dc.okm.affiliatedauthorJärveläinen, Hannu
dc.okm.discipline1182 Biochemistry, cell and molecular biologyen_GB
dc.okm.discipline3122 Cancersen_GB
dc.okm.discipline1182 Biokemia, solu- ja molekyylibiologiafi_FI
dc.okm.discipline3122 Syöpätauditfi_FI
dc.okm.internationalcopublicationnot an international co-publication
dc.okm.internationalityInternational publication
dc.okm.typeA2 Scientific Article
dc.publisherBritish Pharmacological Society
dc.publisher.countryUnited Kingdomen_GB
dc.publisher.countryBritanniafi_FI
dc.publisher.country-codeGB
dc.relation.doi10.1111/bph.14180
dc.relation.ispartofjournalBritish Journal of Pharmacology
dc.relation.issue1
dc.relation.volume176
dc.source.identifierhttps://www.utupub.fi/handle/10024/156925
dc.titleDecorin-mediated oncosuppression – a potential future adjuvant therapy for human epithelial cancers
dc.year.issued2019

Tiedostot

Näytetään 1 - 1 / 1
Name:
Sainio_et_al-2017-British_Journal_of_Pharmacology.pdf
Size:
681.02 KB
Format:
Adobe Portable Document Format
Description:
Publisher's PDF
Lataa

Kokoelmat

Rinnakkaistallenteet