SYNTHESIS OF 7-SUBSTITUTED 3-beta-D-RIBOFURANOSYL-3H-IMIDAZO[2,1-i]PURINES

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dc.contributor.authorKarskela T
dc.contributor.authorKlika KD
dc.contributor.authorLonnberg H
dc.contributor.organizationfi=lääkekehityksen kemia|en=Pharmaseutical Chemistry|
dc.contributor.organization-code1.2.246.10.2458963.20.93793350823
dc.converis.publication-id3140896
dc.converis.urlhttps://research.utu.fi/converis/portal/Publication/3140896
dc.date.accessioned2022-10-28T14:14:56Z
dc.date.available2022-10-28T14:14:56Z
dc.description.abstractA method for the synthesis of 7-substituted 3-beta-D-ribofuranosyl-3H-imidazo[2,1-i]purines has been devised whereby compounds were prepared in a few steps from a common intermediate, 3-(2',3'-O-isopropylidene-beta-D-ribofuranosyl)-3H-imidazo[2,1-i]purine-7-carbaldehyde, obtained from the reaction of 2',3'-O-isopropylideneadenosine with bromomalonaldehyde. The formyl group of the carbaldehyde was subsequently reductively aminated and the resulting secondary amines were then further derivatized either by acylation, lactamization or reductive alkylation.
dc.format.pagerange1043
dc.format.pagerange1054
dc.identifier.jour-issn0010-0765
dc.identifier.olddbid187161
dc.identifier.oldhandle10024/170255
dc.identifier.urihttps://www.utupub.fi/handle/11111/42541
dc.identifier.urnURN:NBN:fi-fe2021042715079
dc.language.isoen
dc.okm.affiliatedauthorLönnberg, Harri
dc.okm.affiliatedauthorKarskela, Tuomas
dc.okm.discipline116 Chemical sciencesen_GB
dc.okm.discipline116 Kemiafi_FI
dc.okm.internationalcopublicationnot an international co-publication
dc.okm.internationalityInternational publication
dc.okm.typeA1 ScientificArticle
dc.publisherINST ORGANIC CHEM AND BIOCHEM
dc.publisher.countryGermanyen_GB
dc.publisher.countrySaksafi_FI
dc.publisher.country-codeDE
dc.relation.doi10.1135/cccc2011069
dc.relation.ispartofjournalCollection of Czechoslovak Chemical Communications
dc.relation.issue8
dc.relation.volume76
dc.source.identifierhttps://www.utupub.fi/handle/10024/170255
dc.titleSYNTHESIS OF 7-SUBSTITUTED 3-beta-D-RIBOFURANOSYL-3H-IMIDAZO[2,1-i]PURINES
dc.year.issued2011

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