Assembly of split aptamers by dynamic pH-responsive covalent ligation

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dc.contributor.authorAho Aapo
dc.contributor.authorVirta Pasi
dc.contributor.organizationfi=lääkekehityksen kemia|en=Pharmaseutical Chemistry|
dc.contributor.organization-code1.2.246.10.2458963.20.93793350823
dc.converis.publication-id179466137
dc.converis.urlhttps://research.utu.fi/converis/portal/Publication/179466137
dc.date.accessioned2025-08-27T23:54:40Z
dc.date.available2025-08-27T23:54:40Z
dc.description.abstractReversible pH-responsive N-methoxyoxazolidine formation is used to ligate split aptamer fragments. Two twice-split models and one thrice-split model of CBA (cocaine-binding aptamer) were examined. The aptamer assembly was dynamic, proportional to the substrate concentration and occurred without interfering background ligation.
dc.format.pagerange5689
dc.format.pagerange5692
dc.identifier.jour-issn1359-7345
dc.identifier.olddbid204850
dc.identifier.oldhandle10024/187877
dc.identifier.urihttps://www.utupub.fi/handle/11111/53545
dc.identifier.urlhttps://doi.org/10.1039/D3CC01158E
dc.identifier.urnURN:NBN:fi-fe2023051243654
dc.language.isoen
dc.okm.affiliatedauthorAho, Aapo
dc.okm.affiliatedauthorVirta, Pasi
dc.okm.discipline116 Chemical sciencesen_GB
dc.okm.discipline116 Kemiafi_FI
dc.okm.internationalcopublicationnot an international co-publication
dc.okm.internationalityInternational publication
dc.okm.typeA1 ScientificArticle
dc.publisherROYAL SOC CHEMISTRY
dc.publisher.countryUnited Kingdomen_GB
dc.publisher.countryBritanniafi_FI
dc.publisher.country-codeGB
dc.relation.doi10.1039/d3cc01158e
dc.relation.ispartofjournalChemical Communications
dc.relation.issue38
dc.relation.volume59
dc.source.identifierhttps://www.utupub.fi/handle/10024/187877
dc.titleAssembly of split aptamers by dynamic pH-responsive covalent ligation
dc.year.issued2023

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