A genome-wide association meta-analysis on lipoprotein (a) concentrations adjusted for apolipoprotein (a) isoforms

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dc.contributor.authorMack S
dc.contributor.authorCoassin S
dc.contributor.authorRueedi R
dc.contributor.authorYousri NA
dc.contributor.authorSeppala I
dc.contributor.authorGieger C
dc.contributor.authorSchonherr S
dc.contributor.authorForer L
dc.contributor.authorErhart G
dc.contributor.authorMarques-Vidal P
dc.contributor.authorRied JS
dc.contributor.authorWaeber G
dc.contributor.authorBergmann S
dc.contributor.authorDahnhardt D
dc.contributor.authorStockl A
dc.contributor.authorRaitakari OT
dc.contributor.authorKhahonen M
dc.contributor.authorPeters A
dc.contributor.authorMeitinger T
dc.contributor.authorStrauch K
dc.contributor.authorKedenko L
dc.contributor.authorPaulweber B
dc.contributor.authorLehtimaki T
dc.contributor.authorHunt SC
dc.contributor.authorVollenweider P
dc.contributor.authorLamina C
dc.contributor.authorKronenberg F
dc.contributor.organizationfi=sydäntutkimuskeskus|en=Cardiovascular Medicine (CAPC)|
dc.contributor.organizationfi=tyks, vsshp|en=tyks, varha|
dc.contributor.organization-code1.2.246.10.2458963.20.35734063924
dc.converis.publication-id26622045
dc.converis.urlhttps://research.utu.fi/converis/portal/Publication/26622045
dc.date.accessioned2022-10-28T13:24:38Z
dc.date.available2022-10-28T13:24:38Z
dc.description.abstractHigh lipoprotein (a) [Lp(a)] concentrations are an independent risk factor for cardiovascular outcomes. Concentrations are strongly influenced by apo(a) kringle IV repeat isoforms. We aimed to identify genetic loci associated with Lp(a) concentrations using data from five genome- wide association studies (n = 13,781). We identified 48 independent SNPs in the LPA and 1 SNP in the APOE gene region to be significantly associated with Lp(a) concentrations. We also adjusted for apo(a) isoforms to identify loci affecting Lp(a) levels independently from them, which resulted in 31 SNPs (30 in the LPA, 1 in the APOE gene region). Seven
dc.format.pagerange1834
dc.format.pagerange1844
dc.identifier.jour-issn0022-2275
dc.identifier.olddbid181891
dc.identifier.oldhandle10024/164985
dc.identifier.urihttps://www.utupub.fi/handle/11111/38987
dc.identifier.urnURN:NBN:fi-fe2021042717174
dc.language.isoen
dc.okm.affiliatedauthorRaitakari, Olli
dc.okm.affiliatedauthorDataimport, tyks, vsshp
dc.okm.discipline3121 Internal medicineen_GB
dc.okm.discipline3121 Sisätauditfi_FI
dc.okm.internationalcopublicationinternational co-publication
dc.okm.internationalityInternational publication
dc.okm.typeA1 ScientificArticle
dc.publisherAMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
dc.publisher.countryUnited Statesen_GB
dc.publisher.countryYhdysvallat (USA)fi_FI
dc.publisher.country-codeUS
dc.relation.doi10.1194/jlr.M076232
dc.relation.ispartofjournalJournal of Lipid Research
dc.relation.issue10
dc.relation.volume58
dc.source.identifierhttps://www.utupub.fi/handle/10024/164985
dc.titleA genome-wide association meta-analysis on lipoprotein (a) concentrations adjusted for apolipoprotein (a) isoforms
dc.year.issued2017

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