Host poly(ADP-ribose) polymerases (PARPs) in acute and chronic bacterial infections

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dc.contributor.authorMoona Miettinen
dc.contributor.authorMadhukar Vedanthama
dc.contributor.authorArto T. Pulliainen
dc.contributor.organizationfi=biolääketieteen laitos|en=Institute of Biomedicine|
dc.contributor.organization-code1.2.246.10.2458963.20.77952289591
dc.converis.publication-id41661251
dc.converis.urlhttps://research.utu.fi/converis/portal/Publication/41661251
dc.date.accessioned2022-10-28T12:44:30Z
dc.date.available2022-10-28T12:44:30Z
dc.description.abstract<div><div><h2>Abstract</h2><div><p>Protein ADP-ribosylation is a reversible post-translational modification, which alters protein activity, localization, interactome or stability, leading to perturbation of cell signaling. This review summarizes the emerging data indicating that host cell ADP-ribosylating enzymes, poly(ADP-ribose) polymerases (PARPs), influence the course of a bacterial infection, in parallel to ADP-ribosylating bacterial toxins. Host cell PARP targeting could be an efficient therapeutic approach to treat certain bacterial infections, possibly by repurposing the approved or clinical trial PARP inhibitors developed for cancer therapy.</p></div></div></div><div><div><br /></div></div>
dc.format.pagerange423
dc.format.pagerange431
dc.identifier.eissn1769-714X
dc.identifier.jour-issn1286-4579
dc.identifier.olddbid178632
dc.identifier.oldhandle10024/161726
dc.identifier.urihttps://www.utupub.fi/handle/11111/36133
dc.identifier.urnURN:NBN:fi-fe2021042826352
dc.language.isoen
dc.okm.affiliatedauthorSakari, Moona
dc.okm.affiliatedauthorVedantham, Madhukar
dc.okm.affiliatedauthorPulliainen, Arto
dc.okm.discipline3111 Biomedicineen_GB
dc.okm.discipline3111 Biolääketieteetfi_FI
dc.okm.internationalcopublicationnot an international co-publication
dc.okm.internationalityInternational publication
dc.okm.typeA2 Scientific Article
dc.publisherElsevier Masson SAS
dc.publisher.countryFranceen_GB
dc.publisher.countryRanskafi_FI
dc.publisher.country-codeFR
dc.relation.doi10.1016/j.micinf.2019.06.002
dc.relation.ispartofjournalMicrobes and Infection
dc.relation.issue10
dc.relation.volume21
dc.source.identifierhttps://www.utupub.fi/handle/10024/161726
dc.titleHost poly(ADP-ribose) polymerases (PARPs) in acute and chronic bacterial infections
dc.year.issued2019

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