Genome-wide meta-analyses reveal novel loci for verbal short-term memory and learning

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dc.contributor.authorLahti Jari
dc.contributor.authorTuominen Samuli
dc.contributor.authorYang Qiong
dc.contributor.authorPergola Giulio
dc.contributor.authorAhmad Shahzad
dc.contributor.authorAmin Najaf
dc.contributor.authorArmstrong Nicola J.
dc.contributor.authorBeiser Alexa
dc.contributor.authorBey Katharina
dc.contributor.authorBis Joshua C.
dc.contributor.authorBoerwinkle Eric
dc.contributor.authorBressler Jan
dc.contributor.authorCampbell Archie
dc.contributor.authorCampbell Harry
dc.contributor.authorChen Qiang
dc.contributor.authorCorley Janie
dc.contributor.authorCox Simon R.
dc.contributor.authorDavies Gail
dc.contributor.authorDe Jager Philip L.
dc.contributor.authorDerks Eske M.
dc.contributor.authorFaul Jessica D.
dc.contributor.authorFitzpatrick Annette L.
dc.contributor.authorFohner Alison E.
dc.contributor.authorFord Ian
dc.contributor.authorFornage Myriam
dc.contributor.authorGerring Zachary
dc.contributor.authorGrabe Hans J.
dc.contributor.authorGrodstein Francine
dc.contributor.authorGudnason Vilmundur
dc.contributor.authorSimonsick Eleanor
dc.contributor.authorHolliday Elizabeth G.
dc.contributor.authorJoshi Peter K.
dc.contributor.authorKajantie Eero
dc.contributor.authorKaprio Jaakko
dc.contributor.authorKarell Pauliina
dc.contributor.authorKleineidam Luca
dc.contributor.authorKnol Maria J.
dc.contributor.authorKochan Nicole A.
dc.contributor.authorKwok John B.
dc.contributor.authorLeber Markus
dc.contributor.authorLam Max
dc.contributor.authorLee Teresa
dc.contributor.authorLi Shuo
dc.contributor.authorLoukola Anu
dc.contributor.authorLuck Tobias
dc.contributor.authorMarioni Riccardo E.
dc.contributor.authorMather Karen A.
dc.contributor.authorMedland Sarah
dc.contributor.authorMirza Saira S.
dc.contributor.authorNalls Mike A.
dc.contributor.authorNho Kwangsik
dc.contributor.authorO’Donnell Adrienne
dc.contributor.authorOldmeadow Christopher
dc.contributor.authorPainter Jodie
dc.contributor.authorPattie Alison
dc.contributor.authorReppermund Simone
dc.contributor.authorRisacher Shannon L.
dc.contributor.authorRose Richard J.
dc.contributor.authorSadashivaiah Vijay
dc.contributor.authorScholz Markus
dc.contributor.authorSatizabal Claudia L.
dc.contributor.authorSchofield Peter W.
dc.contributor.authorSchraut Katharina E.
dc.contributor.authorScott Rodney J.
dc.contributor.authorSimino Jeannette
dc.contributor.authorSmith Albert V.
dc.contributor.authorSmith Jennifer A.
dc.contributor.authorStott David J.
dc.contributor.authorSurakka Ida
dc.contributor.authorTeumer Alexander
dc.contributor.authorThalamuthu Anbupalam
dc.contributor.authorTrompet Stella
dc.contributor.authorTurner Stephen T.
dc.contributor.authorvan der Lee Sven J.
dc.contributor.authorVillringer Arno
dc.contributor.authorVölker Uwe
dc.contributor.authorWilson Robert S.
dc.contributor.authorWittfeld Katharina
dc.contributor.authorVuoksimaa Eero
dc.contributor.authorXia Rui
dc.contributor.authorYaffe Kristine
dc.contributor.authorYu Lei
dc.contributor.authorZare Habil
dc.contributor.authorZhao Wei
dc.contributor.authorAmes David
dc.contributor.authorAttia John
dc.contributor.authorBennett David A.
dc.contributor.authorBrodaty Henry
dc.contributor.authorChasman Daniel I.
dc.contributor.authorGoldman Aaron L.
dc.contributor.authorHayward Caroline
dc.contributor.authorIkram M. Arfan
dc.contributor.authorJukema J. Wouter
dc.contributor.authorKardia Sharon L. R.
dc.contributor.authorLencz Todd
dc.contributor.authorLoeffler Markus
dc.contributor.authorMattay Venkata S.
dc.contributor.authorPalotie Aarno
dc.contributor.authorPsaty Bruce M.
dc.contributor.authorRamirez Alfredo
dc.contributor.authorRidker Paul M.
dc.contributor.authorRiedel-Heller Steffi G.
dc.contributor.authorSachdev Perminder S.
dc.contributor.authorSaykin Andrew J.
dc.contributor.authorScherer Martin
dc.contributor.authorSchofield Peter R.
dc.contributor.authorSidney Stephen
dc.contributor.authorStarr John M.
dc.contributor.authorTrollor Julian
dc.contributor.authorUlrich William
dc.contributor.authorWagner Michael
dc.contributor.authorWeir David R.
dc.contributor.authorWilson James F.
dc.contributor.authorWright Margaret J.
dc.contributor.authorWeinberger Daniel R.
dc.contributor.authorDebette Stephanie
dc.contributor.authorEriksson Johan G.
dc.contributor.authorMosley Thomas H. Jr.
dc.contributor.authorLauner Lenore J.
dc.contributor.authorvan Duijn Cornelia M.
dc.contributor.authorDeary Ian J.
dc.contributor.authorSeshadri Sudha Räikkönen Katri
dc.contributor.organizationfi=psykologia|en=Psychology|
dc.contributor.organization-code2603103
dc.converis.publication-id176277467
dc.converis.urlhttps://research.utu.fi/converis/portal/Publication/176277467
dc.date.accessioned2025-08-28T01:55:43Z
dc.date.available2025-08-28T01:55:43Z
dc.description.abstractUnderstanding the genomic basis of memory processes may help in combating neurodegenerative disorders. Hence, we examined the associations of common genetic variants with verbal short-term memory and verbal learning in adults without dementia or stroke (N = 53,637). We identified novel loci in the intronic region of CDH18, and at 13q21 and 3p21.1, as well as an expected signal in the APOE/APOC1/TOMM40 region. These results replicated in an independent sample. Functional and bioinformatic analyses supported many of these loci and further implicated POC1. We showed that polygenic score for verbal learning associated with brain activation in right parieto-occipital region during working memory task. Finally, we showed genetic correlations of these memory traits with several neurocognitive and health outcomes. Our findings suggest a role of several genomic loci in verbal memory processes.
dc.identifier.eissn1476-5578
dc.identifier.jour-issn1359-4184
dc.identifier.olddbid208291
dc.identifier.oldhandle10024/191318
dc.identifier.urihttps://www.utupub.fi/handle/11111/57699
dc.identifier.urlhttps://doi.org/10.1038/s41380-022-01710-8
dc.identifier.urnURN:NBN:fi-fe2022091358909
dc.language.isoen
dc.okm.affiliatedauthorLahti, Jari
dc.okm.affiliatedauthorDataimport, Psykologia
dc.okm.discipline1182 Biochemistry, cell and molecular biologyen_GB
dc.okm.discipline1182 Biokemia, solu- ja molekyylibiologiafi_FI
dc.okm.internationalcopublicationinternational co-publication
dc.okm.internationalityInternational publication
dc.okm.typeA1 ScientificArticle
dc.publisherSpringer Nature
dc.publisher.countryUnited Statesen_GB
dc.publisher.countryYhdysvallat (USA)fi_FI
dc.publisher.country-codeUS
dc.relation.doi10.1038/s41380-022-01710-8
dc.relation.ispartofjournalMolecular Psychiatry
dc.source.identifierhttps://www.utupub.fi/handle/10024/191318
dc.titleGenome-wide meta-analyses reveal novel loci for verbal short-term memory and learning
dc.year.issued2022

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