p62/SQSTM1 droplets initiate autophagosome biogenesis and oxidative stress control

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dc.contributor.authorEskelinen Eeva-Liisa
dc.contributor.authorKageyama Shun
dc.contributor.authorKomatsu Masaaki
dc.contributor.organizationfi=biolääketieteen laitos|en=Institute of Biomedicine|
dc.contributor.organization-code1.2.246.10.2458963.20.77952289591
dc.converis.publication-id53412717
dc.converis.urlhttps://research.utu.fi/converis/portal/Publication/53412717
dc.date.accessioned2022-10-27T11:48:59Z
dc.date.available2022-10-27T11:48:59Z
dc.description.abstractSelective autophagy contributes to the degradation of condensates, such as sequestosome 1-bodies, also called p62/SQSTM1-bodies. We showed that endogenous p62 forms gel-like structures, which serve as platforms for autophagosome formation and nuclear factor erythroid 2-related factor 2 (NRF2) activation. Further, p62-mediated NRF2 activation is not cytotoxic, but combination of NRF2 activation with impaired bulk and selective autophagy causes liver injury.
dc.identifier.jour-issn2372-3556
dc.identifier.olddbid172044
dc.identifier.oldhandle10024/155138
dc.identifier.urihttps://www.utupub.fi/handle/11111/29706
dc.identifier.urnURN:NBN:fi-fe2021042821164
dc.language.isoen
dc.okm.affiliatedauthorEskelinen, Eeva-Liisa
dc.okm.discipline1182 Biochemistry, cell and molecular biologyen_GB
dc.okm.discipline3111 Biomedicineen_GB
dc.okm.discipline1182 Biokemia, solu- ja molekyylibiologiafi_FI
dc.okm.discipline3111 Biolääketieteetfi_FI
dc.okm.internationalcopublicationinternational co-publication
dc.okm.internationalityInternational publication
dc.okm.typeB1 Scientific Journal
dc.publisherTAYLOR & FRANCIS INC
dc.publisher.countryUnited Statesen_GB
dc.publisher.countryYhdysvallat (USA)fi_FI
dc.publisher.country-codeUS
dc.relation.articlenumberARTN 1890990
dc.relation.doi10.1080/23723556.2021.1890990
dc.relation.ispartofjournalMolecular & Cellular Oncology
dc.relation.issue2
dc.relation.volume8
dc.source.identifierhttps://www.utupub.fi/handle/10024/155138
dc.titlep62/SQSTM1 droplets initiate autophagosome biogenesis and oxidative stress control
dc.year.issued2021

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