Therapeutic Potential of Targeting the SUMO Pathway in Cancer

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dc.contributor.authorKukkula Antti
dc.contributor.authorOjala Veera K.
dc.contributor.authorMendez Lourdes M
dc.contributor.authorSistonen Lea
dc.contributor.authorElenius Klaus
dc.contributor.authorSundvall Maria
dc.contributor.organizationfi=biolääketieteen laitos|en=Institute of Biomedicine|
dc.contributor.organization-code1.2.246.10.2458963.20.77952289591
dc.converis.publication-id67344521
dc.converis.urlhttps://research.utu.fi/converis/portal/Publication/67344521
dc.date.accessioned2025-08-28T00:41:38Z
dc.date.available2025-08-28T00:41:38Z
dc.description.abstract<p> The small ubiquitin-like modifier (SUMO) pathway regulates the hallmark properties of cancer cells. Moreover, alterations in activity and in levels of SUMO machinery components have been observed in human cancer. Due to the reversible nature of this post-translational protein modification, the balance between SUMOylation and the removal of SUMO is critical. Early-phase clinical trials are currently evaluating the safety and efficacy of SUMO pathway inhibition in cancer patients. In this comprehensive review, we critically discuss the potential of targeting the SUMO pathway as a therapeutic option for cancer. <br></p>
dc.identifier.eissn2072-6694
dc.identifier.jour-issn2072-6694
dc.identifier.olddbid206217
dc.identifier.oldhandle10024/189244
dc.identifier.urihttps://www.utupub.fi/handle/11111/44439
dc.identifier.urlhttps://doi.org/10.3390/cancers13174402
dc.identifier.urnURN:NBN:fi-fe2021100750224
dc.language.isoen
dc.okm.affiliatedauthorKukkula, Antti
dc.okm.affiliatedauthorOjala, Veera
dc.okm.affiliatedauthorSistonen, Lea
dc.okm.affiliatedauthorElenius, Klaus
dc.okm.affiliatedauthorSundvall, Maria
dc.okm.affiliatedauthorDataimport, MediCity
dc.okm.affiliatedauthorDataimport, tyks, vsshp
dc.okm.discipline3111 Biomedicineen_GB
dc.okm.internationalcopublicationinternational co-publication
dc.okm.internationalityInternational publication
dc.okm.typeA2 Scientific Article
dc.publisherMDPI
dc.publisher.countrySwitzerlanden_GB
dc.publisher.countrySveitsifi_FI
dc.publisher.country-codeCH
dc.publisher.placeBasel
dc.relation.articlenumber4402
dc.relation.doi10.3390/cancers13174402
dc.relation.ispartofjournalCancers
dc.relation.issue17
dc.relation.volume13
dc.source.identifierhttps://www.utupub.fi/handle/10024/189244
dc.titleTherapeutic Potential of Targeting the SUMO Pathway in Cancer
dc.year.issued2021

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