Progressive dopaminergic defect in a patient with primary progressive multiple sclerosis

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dc.contributor.authorKaasinen Valtteri
dc.contributor.authorJoutsa Juho
dc.contributor.authorRissanen Eero
dc.contributor.authorAiras Laura
dc.contributor.authorSoilu-Hänninen Merja
dc.contributor.authorNoponen Tommi
dc.contributor.organizationfi=biolääketieteen laitos|en=Institute of Biomedicine|
dc.contributor.organizationfi=kliininen laitos|en=Department of Clinical Medicine|
dc.contributor.organizationfi=kliiniset neurotieteet|en=Clinical Neurosciences|
dc.contributor.organizationfi=psykiatria|en=Psychiatry|
dc.contributor.organizationfi=tyks, vsshp|en=tyks, varha|
dc.contributor.organization-code1.2.246.10.2458963.20.16217176722
dc.contributor.organization-code1.2.246.10.2458963.20.61334543354
dc.contributor.organization-code1.2.246.10.2458963.20.74845969893
dc.contributor.organization-code1.2.246.10.2458963.20.77952289591
dc.converis.publication-id43713416
dc.converis.urlhttps://research.utu.fi/converis/portal/Publication/43713416
dc.date.accessioned2022-10-27T11:49:07Z
dc.date.available2022-10-27T11:49:07Z
dc.description.abstract<p>Dopamine has a modulatory role in a number of autoimmune diseases, but there are no published cases of longitudinal dopaminergic imaging in multiple sclerosis (MS). Here we report a patient with primary progressive multiple sclerosis (PPMS) who was scanned twice with brain dopamine transporter single photon emission computed tomography (SPECT) with an interval of four years. The results showed a loss of tracer binding that corresponded to a 4–7 fold steeper decline than in normal ageing. The finding points to a relevant role of nigrostriatal dopaminergic degeneration in the pathological process of PPMS.<br></p>
dc.identifier.eissn2211-0356
dc.identifier.jour-issn2211-0348
dc.identifier.olddbid172061
dc.identifier.oldhandle10024/155155
dc.identifier.urihttps://www.utupub.fi/handle/11111/29705
dc.identifier.urnURN:NBN:fi-fe2021042821176
dc.language.isoen
dc.okm.affiliatedauthorKaasinen, Valtteri
dc.okm.affiliatedauthorJoutsa, Juho
dc.okm.affiliatedauthorRissanen, Eero
dc.okm.affiliatedauthorAiras, Laura
dc.okm.affiliatedauthorSoilu-Hänninen, Merja
dc.okm.affiliatedauthorNoponen, Tommi
dc.okm.affiliatedauthorDataimport, tyks, vsshp
dc.okm.discipline3124 Neurology and psychiatryen_GB
dc.okm.discipline3124 Neurologia ja psykiatriafi_FI
dc.okm.internationalcopublicationnot an international co-publication
dc.okm.internationalityInternational publication
dc.okm.typeB1 Scientific Journal
dc.publisherElsevier B.V.
dc.publisher.countryNetherlandsen_GB
dc.publisher.countryAlankomaatfi_FI
dc.publisher.country-codeNL
dc.relation.articlenumber101385
dc.relation.doi10.1016/j.msard.2019.101385
dc.relation.ispartofjournalMultiple Sclerosis and Related Disorders
dc.relation.volume36
dc.source.identifierhttps://www.utupub.fi/handle/10024/155155
dc.titleProgressive dopaminergic defect in a patient with primary progressive multiple sclerosis
dc.year.issued2019

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