Synthesis, characterization and biocompatibility of guar gum-benzoic acid

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dc.contributor.authorLe Trung-Anh
dc.contributor.authorGuo Yong
dc.contributor.authorZhou Jun-Nian
dc.contributor.authorYan Jiaqi
dc.contributor.authorZhang Hongbo
dc.contributor.authorHuynh Tan-Phat
dc.contributor.organizationfi=Turun biotiedekeskus|en=Turku Bioscience Centre|
dc.contributor.organization-code1.2.246.10.2458963.20.18586209670
dc.converis.publication-id178553525
dc.converis.urlhttps://research.utu.fi/converis/portal/Publication/178553525
dc.date.accessioned2025-08-28T00:04:24Z
dc.date.available2025-08-28T00:04:24Z
dc.description.abstractA novel chemical functionalization of guar gum (GG) by benzoic acid (BA) via nucleophilic substitution reaction in aqueous solution has been reported. BA moieties are chosen due to coordination chemistry of carboxylic acid moieties, hydrophobicity and intermolecular interaction of aromatic rings. The presence of conjugated BA on guar gum-benzoic acid (GG-BA) with grafting density of 5.5% is confirmed by 1H NMR. Amorphous GG-BA with irregular morphology has been studied by UV-Vis, FTIR, XRD, SEM, TEM, TGA, computational chemistry and contact angle measurement. GG-BA in a concentration range from 0 to 4000 mu g mL-1 has good biocompatibility to mouse embryonic fibroblasts (MEF), human mammary epithelial cells (MCF-10A) after 48 and 72 h of treatment using WST-1 assay. GG-BA shows great potential for the development of biomaterials such as bioadhesives, hydrogels, and coacervates.
dc.format.pagerange110
dc.format.pagerange116
dc.identifier.eissn1879-0003
dc.identifier.jour-issn0141-8130
dc.identifier.olddbid205129
dc.identifier.oldhandle10024/188156
dc.identifier.urihttps://www.utupub.fi/handle/11111/53917
dc.identifier.urlhttps://doi.org/10.1016/j.ijbiomac.2021.11.180
dc.identifier.urnURN:NBN:fi-fe2023021627454
dc.language.isoen
dc.okm.affiliatedauthorZhang, Hongbo
dc.okm.discipline3111 Biomedicineen_GB
dc.okm.discipline3111 Biolääketieteetfi_FI
dc.okm.internationalcopublicationinternational co-publication
dc.okm.internationalityInternational publication
dc.okm.typeA1 ScientificArticle
dc.publisherELSEVIER
dc.publisher.countryNetherlandsen_GB
dc.publisher.countryAlankomaatfi_FI
dc.publisher.country-codeNL
dc.relation.doi10.1016/j.ijbiomac.2021.11.180
dc.relation.ispartofjournalInternational Journal of Biological Macromolecules
dc.relation.volume194
dc.source.identifierhttps://www.utupub.fi/handle/10024/188156
dc.titleSynthesis, characterization and biocompatibility of guar gum-benzoic acid
dc.year.issued2022

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