Application of advanced brain positron emission tomography-based molecular imaging for a biological framework in neurodegenerative proteinopathies

Abstract

<h3>Introduction</h3><p>A rapid transition from a clinical‐based classification to a pathology‐based classification of neurodegenerative conditions, largely promoted by the increasing availability of imaging biomarkers, is emerging. The Framework for Innovative Multi‐tracer molecular Brain Imaging, funded by the EU Joint Program ‐ Neurodegenerative Disease Research 2016 “Working Groups for Harmonisation and Alignment in Brain Imaging Methods for Neurodegeneration,” aimed at providing a roadmap for the applications of established and new molecular imaging techniques in dementia.</p><h3>Methods</h3><p>We consider current and future implications of adopting a pathology‐based framework for the use and development of positron emission tomography techniques.</p><h3>Results</h3><p>This approach will enhance efforts to understand the multifactorial etiology of Alzheimer's disease and other dementias.</p><h3>Discussion</h3><p>The availability of pathology biomarkers will soon transform clinical and research practice. Crucially, a comprehensive understanding of strengths and caveats of these techniques will promote an informed use to take full advantage of these tools.</p>