Good guy in bad company: How STRNs convert PP2A into an oncoprotein

Tietueen suppeat tiedot
dc.contributor.authorKurppa Kari J
dc.contributor.authorWestermarck Jukka
dc.contributor.organizationfi=MediCity|en=MediCity|
dc.contributor.organizationfi=Turun biotiedekeskus|en=Turku Bioscience Centre|
dc.contributor.organizationfi=biolääketieteen laitos|en=Institute of Biomedicine|
dc.contributor.organization-code1.2.246.10.2458963.20.18586209670
dc.contributor.organization-code1.2.246.10.2458963.20.77952289591
dc.converis.publication-id48901298
dc.converis.urlhttps://research.utu.fi/converis/portal/Publication/48901298
dc.date.accessioned2022-10-28T12:39:47Z
dc.date.available2022-10-28T12:39:47Z
dc.description.abstract<p>Certain Protein Phosphatase 2A (PP2A) complexes are human tumor suppressors. In contrast, a paper in this issue of <em>Cancer Cell</em> and two other recent studies demonstrate that PP2A-STRN3/4 complexes inactivate Hippo tumor suppressor pathway, resulting in YAP activation and tumorigenesis. Furthermore, this new oncogenic phosphatase mechanism may be druggable<br></p>
dc.format.pagerange20
dc.format.pagerange22
dc.identifier.eissn1878-3686
dc.identifier.jour-issn1535-6108
dc.identifier.olddbid178057
dc.identifier.oldhandle10024/161151
dc.identifier.urihttps://www.utupub.fi/handle/11111/35299
dc.identifier.urnURN:NBN:fi-fe2021042825716
dc.language.isoen
dc.okm.affiliatedauthorKurppa, Kari
dc.okm.affiliatedauthorDataimport, MediCity
dc.okm.affiliatedauthorWestermarck, Jukka
dc.okm.discipline3111 Biomedicineen_GB
dc.okm.discipline3111 Biolääketieteetfi_FI
dc.okm.internationalcopublicationnot an international co-publication
dc.okm.internationalityInternational publication
dc.okm.typeB1 Scientific Journal
dc.publisher.countryUnited Statesen_GB
dc.publisher.countryYhdysvallat (USA)fi_FI
dc.publisher.country-codeUS
dc.relation.doi10.1016/j.ccell.2020.06.011
dc.relation.ispartofjournalCancer Cell
dc.relation.issue1
dc.relation.volume38
dc.source.identifierhttps://www.utupub.fi/handle/10024/161151
dc.titleGood guy in bad company: How STRNs convert PP2A into an oncoprotein
dc.year.issued2020

Tiedostot

Näytetään 1 - 1 / 1
Name:
Cancer Cell preview final.pdf
Size:
314.04 KB
Format:
Adobe Portable Document Format
Description:
Final draft
Lataa

Kokoelmat

Rinnakkaistallenteet