Lymphatic research in the human spleen unveils a differentiated splenic sinusoid
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Julkaisu on tekijänoikeussäännösten alainen. Teosta voi lukea ja tulostaa henkilökohtaista käyttöä varten. Käyttö kaupallisiin tarkoituksiin on kielletty.
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Keeping the human body in a healthy condition requires a flawless cooperation between
myriads of physiological systems, the lymphatic system being one of them. While most often
considered to be responsible for immune cell trafficking and mobilization of leukocytes
during immune responses, the lymphatic system plays also a vital role in lipid trafficking
from the intestines and preventing lymphedema by absorbing interstitial fluids leaking out of
the capillaries of the circulatory system.
To effectively fulfil these tasks, the lymphatic system is comprised of multiple organs and
long vessels all over the human body, all complete with complicated pathways to achieve its
functions. For us to study further how the lymphatic system works, we need a solid
understanding regarding the organization, structure and the pathways of the lymphatic
system. While much is known about the lymphatic system and multiple breakthrough
medications have been developed due to this knowledge, there are still a lot of enigmatic
components we do not know much about especially regarding the functionality or even the
organisation of the lymphatic vasculature.
One of these enigmatic components is the human spleen. Throughout history, many
researchers have tried to conclude the existence or absence of lymphatic vessels in the
human spleen. After reviewing available literature, it was concluded that very little is known
about the human splenic microanatomy regarding lymphatic vasculature or cell trafficking.
In this work, we will review the currently available literature of the human splenic
microanatomy in the context of immunity and conduct experiments using novel and
commonly used lymphatic endothelial markers to further investigate the state of lymphatic
vasculature in the human spleen.