Humoral Immunity to Measles, Mumps, Rubella, Diphtheria, Tetanus and Pertussis After Cancer Treatment in Children

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dc.contributor.authorSundell, Susanna
dc.contributor.authorLaine, Miia
dc.contributor.authorJärvelä, Liisa
dc.contributor.authorPeltola, Ville
dc.contributor.authorVuorinen, Tytti
dc.contributor.authorLähteenmäki, Päivi
dc.contributor.authorSchuez-Havupalo, Linnea
dc.contributor.organizationfi=InFLAMES Lippulaiva|en=InFLAMES Flagship|
dc.contributor.organizationfi=biolääketieteen laitos|en=Institute of Biomedicine|
dc.contributor.organizationfi=kliininen laitos|en=Department of Clinical Medicine|
dc.contributor.organizationfi=lastentautioppi|en=Paediatrics and Adolescent Medicine|
dc.contributor.organizationfi=tyks, vsshp|en=tyks, varha|
dc.contributor.organization-code1.2.246.10.2458963.20.40612039509
dc.contributor.organization-code1.2.246.10.2458963.20.61334543354
dc.contributor.organization-code1.2.246.10.2458963.20.68445910604
dc.contributor.organization-code1.2.246.10.2458963.20.77952289591
dc.converis.publication-id498504843
dc.converis.urlhttps://research.utu.fi/converis/portal/Publication/498504843
dc.date.accessioned2025-08-28T00:35:55Z
dc.date.available2025-08-28T00:35:55Z
dc.description.abstract<h3>Background</h3><p>Treatment for pediatric malignancies has distinct effects on the immune system.</p><h3>Aims</h3><p>Our aim was to measure humoral immunity to measles, mumps and rubella (MMR), and diphtheria, tetanus and acellular pertussis (DTaP) vaccines after pediatric cancer treatment.</p><h3>Method</h3><p>We assessed IgG titers of 52 children against the vaccine antigens post-treatment.</p><h3>Results</h3><p>After completed primary vaccination series for MMR and DTaP before treatment, post-treatment there was a considerable proportion of patients with below-reference titers against pertussis, diphtheria and tetanus, but only few subjects showed below-reference titers against measles, mumps and rubella. Our findings may have implications when considering re-vaccination policies.</p>
dc.identifier.eissn2573-8348
dc.identifier.jour-issn2573-8348
dc.identifier.olddbid206013
dc.identifier.oldhandle10024/189040
dc.identifier.urihttps://www.utupub.fi/handle/11111/39679
dc.identifier.urlhttps://doi.org/10.1002/cnr2.70155
dc.identifier.urnURN:NBN:fi-fe2025082787200
dc.language.isoen
dc.okm.affiliatedauthorLaine, Miia
dc.okm.affiliatedauthorJärvelä, Liisa
dc.okm.affiliatedauthorPeltola, Ville
dc.okm.affiliatedauthorVuorinen, Tytti
dc.okm.affiliatedauthorLähteenmäki, Päivi
dc.okm.affiliatedauthorSchuz-Havupalo, Linnea
dc.okm.affiliatedauthorDataimport, tyks, vsshp
dc.okm.discipline3111 Biomedicineen_GB
dc.okm.discipline3121 Internal medicineen_GB
dc.okm.discipline3123 Gynaecology and paediatricsen_GB
dc.okm.discipline3111 Biolääketieteetfi_FI
dc.okm.discipline3121 Sisätauditfi_FI
dc.okm.discipline3123 Naisten- ja lastentauditfi_FI
dc.okm.internationalcopublicationnot an international co-publication
dc.okm.internationalityInternational publication
dc.okm.typeA1 ScientificArticle
dc.publisherWiley
dc.publisher.countryUnited Statesen_GB
dc.publisher.countryYhdysvallat (USA)fi_FI
dc.publisher.country-codeUS
dc.publisher.placeHOBOKEN
dc.relation.articlenumbere70155
dc.relation.doi10.1002/cnr2.70155
dc.relation.ispartofjournalCancer reports
dc.relation.issue5
dc.relation.volume8
dc.source.identifierhttps://www.utupub.fi/handle/10024/189040
dc.titleHumoral Immunity to Measles, Mumps, Rubella, Diphtheria, Tetanus and Pertussis After Cancer Treatment in Children
dc.year.issued2025

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