Advanced Nanomaterials for Myocardial Ischemia-Reperfusion Injury: Bridging Precision Imaging to Targeted Therapy

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dc.contributor.authorLi, Jie
dc.contributor.authorShafiq, Muhammad
dc.contributor.authorYao, Minghua
dc.contributor.authorLiu, Zehua
dc.contributor.authorTian, Ruizhi
dc.contributor.authorZheng, Fangqiao
dc.contributor.authorLu, Chan
dc.contributor.authorMa, Ming
dc.contributor.organizationfi=biolääketieteen laitos|en=Institute of Biomedicine|
dc.contributor.organization-code1.2.246.10.2458963.20.77952289591
dc.converis.publication-id506339709
dc.converis.urlhttps://research.utu.fi/converis/portal/Publication/506339709
dc.date.accessioned2026-04-24T15:49:02Z
dc.description.abstract<p>This review presents functional nanomaterials as integrated theranostic platforms to overcome diagnostic and therapeutic bottlenecks in myocardial ischemia-reperfusion injury (MIRI).<br></p><p>It highlights advances in nano-biosensors for early biomarker detection and multimodal imaging for real-time, precise diagnosis.<br></p><p>Key therapeutic strategies are detailed, including nanozymes for antioxidative stress, biomimetic nanocarriers for targeted delivery, and gas-releasing agents for myocardial repair.<br></p><p>Major translational challenges are discussed, such as low cardiac targeting efficiency, long-term biosafety, and manufacturing scalability of biomimetic systems.</p><p>Future directions emphasize smart, stimuli-responsive nanoplatforms and AI-integrated closed-loop systems for personalized cardiovascular nanomedicine.</p>
dc.format.pagerange43
dc.format.pagerange13
dc.identifier.eissn2590-1834
dc.identifier.urihttps://www.utupub.fi/handle/11111/58558
dc.identifier.urlhttps://doi.org/10.1016/j.smaim.2025.12.003
dc.identifier.urnURN:NBN:fi-fe2026022315393
dc.language.isoen
dc.okm.affiliatedauthorShafiq, Muhammad
dc.okm.discipline217 Medical engineeringen_GB
dc.okm.discipline217 Lääketieteen tekniikkafi_FI
dc.okm.internationalcopublicationinternational co-publication
dc.okm.internationalityInternational publication
dc.okm.typeA2 Scientific Article
dc.publisher.countryChinaen_GB
dc.publisher.countryKiinafi_FI
dc.publisher.country-codeCN
dc.relation.doi10.1016/j.smaim.2025.12.003
dc.relation.ispartofjournalSmart Materials in Medicine
dc.relation.volume7
dc.titleAdvanced Nanomaterials for Myocardial Ischemia-Reperfusion Injury: Bridging Precision Imaging to Targeted Therapy
dc.year.issued2026

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