Complement System in Cutaneous Squamous Cell Carcinoma

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dc.contributor.authorPilvi Riihilä
dc.contributor.authorLiisa Nissinen
dc.contributor.authorJaakko Knuutila
dc.contributor.authorPegah Rahmati Nezhad
dc.contributor.authorKristina Viiklepp
dc.contributor.authorVeli-Matti Kähäri
dc.contributor.organizationfi=iho- ja sukupuolitautioppi|en=Dermatology and Venereology|
dc.contributor.organizationfi=tyks, vsshp|en=tyks, varha|
dc.contributor.organization-code1.2.246.10.2458963.20.39855016430
dc.contributor.organization-code2607305
dc.converis.publication-id42260930
dc.converis.urlhttps://research.utu.fi/converis/portal/Publication/42260930
dc.date.accessioned2022-10-28T13:49:07Z
dc.date.available2022-10-28T13:49:07Z
dc.description.abstractEpidermal keratinocyte-derived cutaneous squamous cell carcinoma (cSCC) is the most common metastatic skin cancer with high mortality rates in the advanced stage. Chronic inflammation is a recognized risk factor for cSCC progression and the complement system, as a part of innate immunity, belongs to the microenvironment of tumors. The complement system is a double-edged sword in cancer, since complement activation is involved in anti-tumor cytotoxicity and immune responses, but it also promotes cancer progression directly and indirectly. Recently, the role of several complement components and inhibitors in the regulation of progression of cSCC has been shown. In this review, we will discuss the role of complement system components and inhibitors as biomarkers and potential new targets for therapeutic intervention in cSCC.
dc.identifier.eissn1422-0067
dc.identifier.jour-issn1661-6596
dc.identifier.olddbid184521
dc.identifier.oldhandle10024/167615
dc.identifier.urihttps://www.utupub.fi/handle/11111/37524
dc.identifier.urnURN:NBN:fi-fe2021042823686
dc.language.isoen
dc.okm.affiliatedauthorRiihilä, Pilvi
dc.okm.affiliatedauthorNissinen, Liisa
dc.okm.affiliatedauthorKnuutila, Jaakko
dc.okm.affiliatedauthorRahmati Nezhad, Pegah
dc.okm.affiliatedauthorViiklepp, Kristina
dc.okm.affiliatedauthorKähäri, Veli-Matti
dc.okm.affiliatedauthorDataimport, tyks, vsshp
dc.okm.discipline3122 Cancersen_GB
dc.okm.discipline3122 Syöpätauditfi_FI
dc.okm.internationalcopublicationnot an international co-publication
dc.okm.internationalityInternational publication
dc.okm.typeA2 Scientific Article
dc.publisherMDPI
dc.publisher.countrySwitzerlanden_GB
dc.publisher.countrySveitsifi_FI
dc.publisher.country-codeCH
dc.relation.articlenumberARTN 3550
dc.relation.doi10.3390/ijms20143550
dc.relation.ispartofjournalInternational Journal of Molecular Sciences
dc.relation.issue14
dc.relation.volume20
dc.source.identifierhttps://www.utupub.fi/handle/10024/167615
dc.titleComplement System in Cutaneous Squamous Cell Carcinoma
dc.year.issued2019

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