Monoacylglycerol lipase inhibitor JZL184 reduces neuroinflammatory response in APdE9 mice and in adult mouse glial cells

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dc.contributor.authorPihlaja R
dc.contributor.authorTakkinen J
dc.contributor.authorEskola O
dc.contributor.authorVasara J
dc.contributor.authorLopez-Picon FR
dc.contributor.authorHaaparanta-Solin M
dc.contributor.authorRinne JO
dc.contributor.organizationfi=PET-keskus|en=Turku PET Centre|
dc.contributor.organizationfi=kliininen laitos|en=Department of Clinical Medicine|
dc.contributor.organizationfi=tyks, vsshp|en=tyks, varha|
dc.contributor.organization-code1.2.246.10.2458963.20.14646305228
dc.contributor.organization-code1.2.246.10.2458963.20.61334543354
dc.contributor.organization-code2609810
dc.contributor.organization-code2609820
dc.converis.publication-id3942434
dc.converis.urlhttps://research.utu.fi/converis/portal/Publication/3942434
dc.date.accessioned2022-10-28T12:34:23Z
dc.date.available2022-10-28T12:34:23Z
dc.description.abstract<p> Conclusions: JZL184 decreased the proinflammatory reactions of microglia and reduced the total A beta burden and its precursors in the APdE9 mouse model. It also reduced the proinflammatory responses of microglia and astrocytes isolated from adult mice.</p>
dc.identifier.eissn1742-2094
dc.identifier.olddbid177408
dc.identifier.oldhandle10024/160502
dc.identifier.urihttps://www.utupub.fi/handle/11111/33585
dc.identifier.urnURN:NBN:fi-fe2021042715441
dc.language.isoen
dc.okm.affiliatedauthorPihlaja, Rea
dc.okm.affiliatedauthorHelin, Jatta
dc.okm.affiliatedauthorEskola, Olli
dc.okm.affiliatedauthorVasara, Jenni
dc.okm.affiliatedauthorLopez Picon, Francisco
dc.okm.affiliatedauthorHaaparanta-Solin, Merja
dc.okm.affiliatedauthorDataimport, tyks, vsshp
dc.okm.affiliatedauthorRinne, Juha
dc.okm.discipline3111 Biomedicineen_GB
dc.okm.discipline3112 Neurosciencesen_GB
dc.okm.discipline3124 Neurology and psychiatryen_GB
dc.okm.discipline3111 Biolääketieteetfi_FI
dc.okm.discipline3112 Neurotieteetfi_FI
dc.okm.discipline3124 Neurologia ja psykiatriafi_FI
dc.okm.internationalcopublicationnot an international co-publication
dc.okm.internationalityInternational publication
dc.okm.typeA1 ScientificArticle
dc.publisherBIOMED CENTRAL LTD
dc.relation.articlenumberARTN 81
dc.relation.doi10.1186/s12974-015-0305-9
dc.relation.ispartofjournalJournal of Neuroinflammation
dc.relation.volume12
dc.source.identifierhttps://www.utupub.fi/handle/10024/160502
dc.titleMonoacylglycerol lipase inhibitor JZL184 reduces neuroinflammatory response in APdE9 mice and in adult mouse glial cells
dc.year.issued2015

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