Influence of Dietary Triacylglycerol Structure on the Accumulation of Docosahexaenoic Acid [22:6(n-3)] in Organs in a Short-Term Feeding Trial with Mildly Omega-3 Deficient Rats

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dc.contributor.authorKulkarni Amruta
dc.contributor.authorLinderborg Kaisa M.
dc.contributor.authorZhao Ai
dc.contributor.authorKallio Heikki
dc.contributor.authorHaraldsson Gudmundur G.
dc.contributor.authorZhang Yumei
dc.contributor.authorYang Baoru
dc.contributor.organizationfi=elintarviketieteet|en=Food Sciences|
dc.contributor.organization-code1.2.246.10.2458963.20.15178954341
dc.contributor.organization-code2610103
dc.converis.publication-id386939849
dc.converis.urlhttps://research.utu.fi/converis/portal/Publication/386939849
dc.date.accessioned2025-08-27T22:37:03Z
dc.date.available2025-08-27T22:37:03Z
dc.description.abstract<p>Scope: To study the effect of positional distribution of docosahexaenoic acid (DHA) in dietary triacylglycerols (TAG) on the tissue fatty acid content and composition of mildly (n-3) deficient rats. <br></p><p>Methods and results: In a 5-day feeding trial, mildly (n-3) deficient rats received 360 mg daily structured TAGs: sn-22:6(n-3)-18:0-18:0, sn-18:0-18:0-22:6(n-3), sn-18:0-22:6(n-3)-18:0, or tristearin. A fifth group receives standard (n-3) adequate feed AIN-93G from birth till the end of the trial. The DHA-fed groups show significantly higher DHA levels in the liver and visceral fat compared to the tristearin or normal feed groups showing that the dose and the short feeding period of DHA were sufficient to restore the DHA content in the organs of (n-3) deficient rats. Feeding sn-1 DHA resulted in higher levels of DHA in the liver TAG compared to sn-3 DHA feeding, although the difference did not reach statistical significance. <br></p><p>Conclusion: These findings indicated a possible difference in the tissue accumulation and/or metabolic fate of DHA from the sn-1 and sn-3 positions of TAG. <br></p><p>© 2024 The Authors. Molecular Nutrition & Food Research published by Wiley-VCH GmbH.</p>
dc.identifier.eissn1613-4133
dc.identifier.jour-issn1613-4125
dc.identifier.olddbid202472
dc.identifier.oldhandle10024/185499
dc.identifier.urihttps://www.utupub.fi/handle/11111/47012
dc.identifier.urlhttps://onlinelibrary.wiley.com/doi/10.1002/mnfr.202300635
dc.identifier.urnURN:NBN:fi-fe2025082785739
dc.language.isoen
dc.okm.affiliatedauthorKulkarni, Amruta
dc.okm.affiliatedauthorLinderborg, Kaisa
dc.okm.affiliatedauthorKallio, Heikki
dc.okm.affiliatedauthorYang, Baoru
dc.okm.discipline414 Agricultural biotechnologyen_GB
dc.okm.discipline414 Maatalouden bioteknologiafi_FI
dc.okm.internationalcopublicationinternational co-publication
dc.okm.internationalityInternational publication
dc.okm.typeA1 ScientificArticle
dc.publisherJohn Wiley and Sons Inc
dc.publisher.countryGermanyen_GB
dc.publisher.countrySaksafi_FI
dc.publisher.country-codeDE
dc.relation.articlenumber2300635
dc.relation.doi10.1002/mnfr.202300635
dc.relation.ispartofjournalMolecular Nutrition and Food Research
dc.relation.issue6
dc.relation.volume68
dc.source.identifierhttps://www.utupub.fi/handle/10024/185499
dc.titleInfluence of Dietary Triacylglycerol Structure on the Accumulation of Docosahexaenoic Acid [22:6(n-3)] in Organs in a Short-Term Feeding Trial with Mildly Omega-3 Deficient Rats
dc.year.issued2024

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