KLB is associated with alcohol drinking, and its gene product β-Klotho is necessary for FGF21 regulation of alcohol preference

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dc.contributor.authorSchumann G
dc.contributor.authorLiu C
dc.contributor.authorO'Reilly P
dc.contributor.authorGao H
dc.contributor.authorSong P
dc.contributor.authorXu B
dc.contributor.authorRuggeri B
dc.contributor.authorAmin N
dc.contributor.authorJia T
dc.contributor.authorPreis S
dc.contributor.authorSegura Lepe M
dc.contributor.authorAkira S
dc.contributor.authorBarbieri C
dc.contributor.authorBaumeister S
dc.contributor.authorCauchi S
dc.contributor.authorClarke TK
dc.contributor.authorEnroth S
dc.contributor.authorFischer K
dc.contributor.authorHällfors J
dc.contributor.authorHarris SE
dc.contributor.authorHieber S
dc.contributor.authorHofer E
dc.contributor.authorHottenga JJ
dc.contributor.authorJohansson å
dc.contributor.authorJoshi PK
dc.contributor.authorKaartinen N
dc.contributor.authorLaitinen J
dc.contributor.authorLemaitre R
dc.contributor.authorLoukola A
dc.contributor.authorLuan J
dc.contributor.authorLyytikäinen LP
dc.contributor.authorMangino M
dc.contributor.authorManichaikul A
dc.contributor.authorMbarek H
dc.contributor.authorMilaneschi Y
dc.contributor.authorMoayyeri A
dc.contributor.authorMukamal K
dc.contributor.authorNelson C
dc.contributor.authorNettleton J
dc.contributor.authorPartinen E
dc.contributor.authorRawal R
dc.contributor.authorRobino A
dc.contributor.authorRose L
dc.contributor.authorSala C
dc.contributor.authorSatoh T
dc.contributor.authorSchmidt R
dc.contributor.authorSchraut K
dc.contributor.authorScott R
dc.contributor.authorSmith AV
dc.contributor.authorStarr JM
dc.contributor.authorTeumer A
dc.contributor.authorTrompet S
dc.contributor.authorUitterlinden AG
dc.contributor.authorVenturini C
dc.contributor.authorVergnaud AC
dc.contributor.authorVerweij N
dc.contributor.authorVitart V
dc.contributor.authorVuckovic D
dc.contributor.authorWedenoja J
dc.contributor.authorYengo L
dc.contributor.authorYu B
dc.contributor.authorZhang W
dc.contributor.authorZhao JH
dc.contributor.authorBoomsma DI
dc.contributor.authorChambers J
dc.contributor.authorChasman DI
dc.contributor.authorDaniela T
dc.contributor.authorde Geus E
dc.contributor.authorDeary I
dc.contributor.authorEriksson JG
dc.contributor.authorEsko T
dc.contributor.authorEulenburg V
dc.contributor.authorFranco OH
dc.contributor.authorFroguel P
dc.contributor.authorGieger C
dc.contributor.authorGrabe HJ
dc.contributor.authorGudnason V
dc.contributor.authorGyllensten U
dc.contributor.authorHarris TB
dc.contributor.authorHartikainen AL
dc.contributor.authorHeath AC
dc.contributor.authorHocking L
dc.contributor.authorHofman A
dc.contributor.authorHuth C
dc.contributor.authorJarvelin MR
dc.contributor.authorJukema JW
dc.contributor.authorKaprio J
dc.contributor.authorKooner JS
dc.contributor.authorKutalik Z
dc.contributor.authorLahti J
dc.contributor.authorLangenberg C
dc.contributor.authorLehtimäki T
dc.contributor.authorLiu Y
dc.contributor.authorMadden PA
dc.contributor.authorMartin N
dc.contributor.authorMorrison A
dc.contributor.authorPenninx B
dc.contributor.authorPirastu N
dc.contributor.authorPsaty B
dc.contributor.authorRaitakari O
dc.contributor.authorRidker P
dc.contributor.authorRose R
dc.contributor.authorRotter JI
dc.contributor.authorSamani NJ
dc.contributor.authorSchmidt H
dc.contributor.authorSpector TD
dc.contributor.authorStott D
dc.contributor.authorStrachan D
dc.contributor.authorTzoulaki I
dc.contributor.authorvan der Harst P
dc.contributor.authorvan Duijn CM
dc.contributor.authorMarques-Vidal P
dc.contributor.authorVollenweider P
dc.contributor.authorWareham NJ
dc.contributor.authorWhitfield JB
dc.contributor.authorWilson J
dc.contributor.authorWolffenbuttel B
dc.contributor.authorBakalkin G
dc.contributor.authorEvangelou E
dc.contributor.authorLiu Y
dc.contributor.authorRice KM
dc.contributor.authorDesrivières S
dc.contributor.authorKliewer SA
dc.contributor.authorMangelsdorf DJ
dc.contributor.authorMüller CP
dc.contributor.authorLevy D
dc.contributor.authorElliott P
dc.contributor.organizationfi=sydäntutkimuskeskus|en=Cardiovascular Medicine (CAPC)|
dc.contributor.organizationfi=tyks, vsshp|en=tyks, varha|
dc.contributor.organization-code1.2.246.10.2458963.20.35734063924
dc.converis.publication-id18248356
dc.converis.urlhttps://research.utu.fi/converis/portal/Publication/18248356
dc.date.accessioned2022-10-28T14:22:32Z
dc.date.available2022-10-28T14:22:32Z
dc.description.abstract<p>Excessive alcohol consumption is a major public health problem worldwide. Although drinking habits are known to be inherited, few genes have been identified that are robustly linked to alcohol drinking. We conducted a genome-wide association metaanalysis and replication study among >105,000 individuals of European ancestry and identified β-Klotho (<em>KLB</em>) as a locus associated with alcohol consumption (rs11940694; <em>P</em> = 9.2 × 10−12). β-Klotho is an obligate coreceptor for the hormone FGF21, which is secreted from the liver and implicated in macronutrient preference in humans. We show that brain-specific β-Klotho KO mice have an increased alcohol preference and that FGF21 inhibits alcohol drinking by acting on the brain. These data suggest that a liver–brain endocrine axis may play an important role in the regulation of alcohol drinking behavior and provide a unique pharmacologic target for reducing alcohol consumption.<br /></p>
dc.format.pagerange14372
dc.format.pagerange14377
dc.identifier.jour-issn0027-8424
dc.identifier.olddbid187894
dc.identifier.oldhandle10024/170988
dc.identifier.urihttps://www.utupub.fi/handle/11111/43351
dc.identifier.urnURN:NBN:fi-fe2021042716232
dc.language.isoen
dc.okm.affiliatedauthorRaitakari, Olli
dc.okm.affiliatedauthorDataimport, tyks, vsshp
dc.okm.discipline1184 Genetics, developmental biology, physiologyen_GB
dc.okm.discipline3121 Internal medicineen_GB
dc.okm.discipline1184 Genetiikka, kehitysbiologia, fysiologiafi_FI
dc.okm.discipline3121 Sisätauditfi_FI
dc.okm.internationalcopublicationinternational co-publication
dc.okm.internationalityInternational publication
dc.okm.typeA1 ScientificArticle
dc.publisherNATL ACAD SCIENCES
dc.publisher.countryUnited Statesen_GB
dc.publisher.countryYhdysvallat (USA)fi_FI
dc.publisher.country-codeUS
dc.relation.doi10.1073/pnas.1611243113
dc.relation.ispartofjournalProceedings of the National Academy of Sciences of the United States of America
dc.relation.issue50
dc.relation.volume113
dc.source.identifierhttps://www.utupub.fi/handle/10024/170988
dc.titleKLB is associated with alcohol drinking, and its gene product β-Klotho is necessary for FGF21 regulation of alcohol preference
dc.year.issued2016

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