A scientific debate: The sword that cleaves chaos of DNAzyme catalysis research

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dc.contributor.authorYan Jiaqi
dc.contributor.authorRan Meixin
dc.contributor.authorZhang Hongbo
dc.contributor.organizationfi=Turun biotiedekeskus|en=Turku Bioscience Centre|
dc.contributor.organizationfi=biolääketieteen laitos|en=Institute of Biomedicine|
dc.contributor.organization-code1.2.246.10.2458963.20.18586209670
dc.contributor.organization-code2607100
dc.converis.publication-id381245251
dc.converis.urlhttps://research.utu.fi/converis/portal/Publication/381245251
dc.date.accessioned2025-08-27T23:17:20Z
dc.date.available2025-08-27T23:17:20Z
dc.description.abstractTherapeutic DNAzymes with RNA depleting effect are multifunctional building blocks for constructing biological materials. In a recent work published in Nature Chemistry, Holliger group and Chaput group had a wonderful debate base on previously reported approach for tailoring DNAzymes with high mRNA cleavage activity in mammalian cells. Their perspective pushes the catalytic mechanism investigation of DNAzymes to a new stage with more standardization and clarity.
dc.format.pagerange21
dc.format.pagerange23
dc.identifier.eissn2949-723X
dc.identifier.olddbid203735
dc.identifier.oldhandle10024/186762
dc.identifier.urihttps://www.utupub.fi/handle/11111/47135
dc.identifier.urlhttps://doi.org/10.1016/j.bmt.2023.01.004
dc.identifier.urnURN:NBN:fi-fe2025082790210
dc.language.isoen
dc.okm.affiliatedauthorRan, Meixin
dc.okm.affiliatedauthorZhang, Hongbo
dc.okm.discipline3111 Biomedicineen_GB
dc.okm.discipline3111 Biolääketieteetfi_FI
dc.okm.internationalcopublicationnot an international co-publication
dc.okm.internationalityInternational publication
dc.okm.typeB1 Scientific Journal
dc.publisherPublishing services by Elsevier on behalf of KeAi Communications
dc.publisher.countryChinaen_GB
dc.publisher.countryKiinafi_FI
dc.publisher.country-codeCN
dc.relation.doi10.1016/j.bmt.2023.01.004
dc.relation.ispartofjournalBiomedical Technology
dc.relation.volume4
dc.source.identifierhttps://www.utupub.fi/handle/10024/186762
dc.titleA scientific debate: The sword that cleaves chaos of DNAzyme catalysis research
dc.year.issued2023

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