Prospective association between the gut microbiome and incident hypertension: a 20-year cohort study

Abstract

<div><div><div><h3>Introduction: </h3><p>Hypertension remains the leading modifiable risk factor attributable to 10.8 million premature deaths. Hence the study of hypertension and gut microbiome as a therapeutic target is very important. Yet the links between the gut microbiome and long-term incidence of hypertension are unknown.</p><h3>Aim: </h3><p>This study assessed the association between gut microbiome and incident hypertension.</p><h3>Method: </h3><p>The study sample consisted of 3311 nonhypertensive individuals (60.7% women) aged 25–74 years who were drawn from the general population in Finland. In the baseline examination performed in the year 2002, the participants underwent a health examination and provided a stool sample. The gut microbiome was assessed using shallow shotgun metagenomic sequencing. Microbiome analyses were performed with Cox proportional hazards model.</p><h3>Results: </h3><p>In total, 675 participants developed hypertension over a follow-up period of nearly 20 years. In multivariable-adjusted models, overall gut microbiome composition was not related to risk of future hypertension. Eight genera, including <em>Agathobaculum, Blautia_A_141780, Blautia_A_141781, Mediterraneibacter_A_155590, Enterocloster</em>, <em>Bariatricus</em>, <em>CAG-317–146760</em>, and <em>CAG-628</em> were significantly associated with incident hypertension in the age-adjusted and sex-adjusted models, but none remained significant in the multivariable-adjusted models. No functional pathways were associated with hypertension risk.</p><h3>Conclusion: </h3><p>Our results do not provide strong evidence for an association between the gut microbiome and risk of future hypertension, especially after adjusting for covariates that are known to influence the gut microbiome.<br></p></div></div></div>