Nucleic acids through condensation of nucleosides and phosphorous acid in the presence of sulfur

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dc.contributor.authorLonnberg T
dc.contributor.organizationfi=lääkekehityksen kemia|en=Pharmaseutical Chemistry|
dc.contributor.organization-code1.2.246.10.2458963.20.93793350823
dc.converis.publication-id17165872
dc.converis.urlhttps://research.utu.fi/converis/portal/Publication/17165872
dc.date.accessioned2022-10-28T14:16:14Z
dc.date.available2022-10-28T14:16:14Z
dc.description.abstractShort phosphorothioate oligonucleotides have been prepared by refluxing an equimolar mixture of thymidine and triethylammonium phosphite in toluene in the presence of elemental sulfur. Desulfurization and subsequent digestion of the products by P1 nuclease revealed that nearly 80% of the internucleosidic linkages thus formed were of the canonical 3',5'-type.
dc.format.pagerange673
dc.identifier.jour-issn2195-951X
dc.identifier.olddbid187287
dc.identifier.oldhandle10024/170381
dc.identifier.urihttps://www.utupub.fi/handle/11111/38624
dc.identifier.urnURN:NBN:fi-fe2021042715615
dc.language.isoen
dc.okm.affiliatedauthorLönnberg, Tuomas
dc.okm.discipline116 Chemical sciencesen_GB
dc.okm.discipline116 Kemiafi_FI
dc.okm.internationalcopublicationnot an international co-publication
dc.okm.internationalityInternational publication
dc.okm.typeA1 ScientificArticle
dc.publisherBEILSTEIN-INSTITUT
dc.publisher.countryGermanyen_GB
dc.publisher.countrySaksafi_FI
dc.publisher.country-codeDE
dc.relation.doi10.3762/bjoc.12.67
dc.relation.ispartofjournalBeilstein Journal of Organic Chemistry
dc.relation.volume12
dc.source.identifierhttps://www.utupub.fi/handle/10024/170381
dc.titleNucleic acids through condensation of nucleosides and phosphorous acid in the presence of sulfur
dc.year.issued2016

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