Establishment of a human induced pluripotent stem cell line (TAUi008-A) derived from a multiple sclerosis patient

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dc.contributor.authorLotila Johanna
dc.contributor.authorHyvärinen Tarja
dc.contributor.authorSkottman Heli
dc.contributor.authorAiras Laura
dc.contributor.authorNarkilahti Susanna
dc.contributor.authorHagman Sanna
dc.contributor.organizationfi=InFLAMES Lippulaiva|en=InFLAMES Flagship|
dc.contributor.organizationfi=kliiniset neurotieteet|en=Clinical Neurosciences|
dc.contributor.organizationfi=tyks, vsshp|en=tyks, varha|
dc.contributor.organization-code1.2.246.10.2458963.20.68445910604
dc.contributor.organization-code1.2.246.10.2458963.20.74845969893
dc.converis.publication-id176045232
dc.converis.urlhttps://research.utu.fi/converis/portal/Publication/176045232
dc.date.accessioned2022-10-28T13:30:06Z
dc.date.available2022-10-28T13:30:06Z
dc.description.abstract<p>Multiple sclerosis (MS) is a complex autoimmune disease of the central nervous system where the main pathogenetic events include demyelination and axonal degeneration. Here, we generated a human induced pluripotent stem cell (hiPSC) line from peripheral blood mononuclear cells of an MS patient utilizing Sendai virus reprogramming. The produced hiPSC line expressed pluripotency markers, differentiated into three germ layers, showed a normal karyotype and was free of virus vectors, transgenes and mycoplasma. Established hiPSCs are a valuable source for studies of MS disease modeling and drug discovery.<br></p>
dc.identifier.jour-issn1873-5061
dc.identifier.olddbid182525
dc.identifier.oldhandle10024/165619
dc.identifier.urihttps://www.utupub.fi/handle/11111/39769
dc.identifier.urlhttps://doi.org/10.1016/j.scr.2022.102865
dc.identifier.urnURN:NBN:fi-fe2022091258631
dc.language.isoen
dc.okm.affiliatedauthorAiras, Laura
dc.okm.affiliatedauthorDataimport, tyks, vsshp
dc.okm.discipline3124 Neurology and psychiatryen_GB
dc.okm.discipline3124 Neurologia ja psykiatriafi_FI
dc.okm.internationalcopublicationnot an international co-publication
dc.okm.internationalityInternational publication
dc.okm.typeA1 ScientificArticle
dc.publisherElsevier B.V.
dc.publisher.countryNetherlandsen_GB
dc.publisher.countryAlankomaatfi_FI
dc.publisher.country-codeNL
dc.relation.doi10.1016/j.scr.2022.102865
dc.relation.ispartofjournalStem Cell Research
dc.relation.volume63
dc.source.identifierhttps://www.utupub.fi/handle/10024/165619
dc.titleEstablishment of a human induced pluripotent stem cell line (TAUi008-A) derived from a multiple sclerosis patient
dc.year.issued2022

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