Autophagy in major human diseases

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dc.contributor.authorKlionsky Daniel J
dc.contributor.authorPetroni Giulia
dc.contributor.authorAmaravadi Ravi K
dc.contributor.authorBaehrecke Eric H
dc.contributor.authorBallabio Andrea
dc.contributor.authorBoya Patricia
dc.contributor.authorBravo-San Pedro José Manuel
dc.contributor.authorCadwell Ken
dc.contributor.authorCecconi Francesco
dc.contributor.authorChoi Augustine M K
dc.contributor.authorChoi Mary E
dc.contributor.authorChu Charleen T
dc.contributor.authorCodogno Patrice
dc.contributor.authorColombo Maria Isabel
dc.contributor.authorCuervo Ana Maria
dc.contributor.authorDeretic Vojo
dc.contributor.authorDikic Ivan
dc.contributor.authorElazar Zvulun
dc.contributor.authorEskelinen Eeva-Liisa
dc.contributor.authorFimia Gian Maria
dc.contributor.authorGewirtz David A
dc.contributor.authorGreen Douglas R
dc.contributor.authorHansen Malene
dc.contributor.authorJäättelä Marja
dc.contributor.authorJohansen Terje
dc.contributor.authorJuhász Gábor
dc.contributor.authorKarantza Vassiliki
dc.contributor.authorKraft Claudine
dc.contributor.authorKroemer Guido
dc.contributor.authorKtistakis Nicholas T
dc.contributor.authorKumar Sharad
dc.contributor.authorLopez-Otin Carlos
dc.contributor.authorMacleod Kay F
dc.contributor.authorMadeo Frank
dc.contributor.authorMartinez Jennifer
dc.contributor.authorMeléndez Alicia
dc.contributor.authorMizushima Noboru
dc.contributor.authorMünz Christian
dc.contributor.authorPenninger Josef M
dc.contributor.authorPerera Rushika M
dc.contributor.authorPiacentini Mauro
dc.contributor.authorReggiori Fulvio
dc.contributor.authorRubinsztein David C
dc.contributor.authorRyan Kevin M
dc.contributor.authorSadoshima Junichi
dc.contributor.authorSantambrogio Laura
dc.contributor.authorScorrano Luca
dc.contributor.authorSimon Hans-Uwe
dc.contributor.authorSimon Anna Katharina
dc.contributor.authorSimonsen Anne
dc.contributor.authorStolz Alexandra
dc.contributor.authorTavernarakis Nektarios
dc.contributor.authorTooze Sharon A
dc.contributor.authorYoshimori Tamotsu
dc.contributor.authorYuan Junying
dc.contributor.authorYue Zhenyu
dc.contributor.authorZhong Qing
dc.contributor.authorGalluzzi Lorenzo
dc.contributor.authorPietrocola Federico
dc.contributor.organizationfi=biolääketieteen laitos|en=Institute of Biomedicine|
dc.contributor.organization-code1.2.246.10.2458963.20.77952289591
dc.converis.publication-id66625661
dc.converis.urlhttps://research.utu.fi/converis/portal/Publication/66625661
dc.date.accessioned2022-10-28T12:25:52Z
dc.date.available2022-10-28T12:25:52Z
dc.description.abstractAutophagy is a core molecular pathway for the preservation of cellular and organismal homeostasis. Pharmacological and genetic interventions impairing autophagy responses promote or aggravate disease in a plethora of experimental models. Consistently, mutations in autophagy-related processes cause severe human pathologies. Here, we review and discuss preclinical data linking autophagy dysfunction to the pathogenesis of major human disorders including cancer as well as cardiovascular, neurodegenerative, metabolic, pulmonary, renal, infectious, musculoskeletal, and ocular disorders.
dc.identifier.eissn1460-2075
dc.identifier.jour-issn0261-4189
dc.identifier.olddbid176333
dc.identifier.oldhandle10024/159427
dc.identifier.urihttps://www.utupub.fi/handle/11111/31698
dc.identifier.urnURN:NBN:fi-fe2021093048222
dc.language.isoen
dc.okm.affiliatedauthorEskelinen, Eeva-Liisa
dc.okm.discipline1182 Biochemistry, cell and molecular biologyen_GB
dc.okm.discipline3111 Biomedicineen_GB
dc.okm.discipline1182 Biokemia, solu- ja molekyylibiologiafi_FI
dc.okm.discipline3111 Biolääketieteetfi_FI
dc.okm.internationalcopublicationinternational co-publication
dc.okm.internationalityInternational publication
dc.okm.typeA2 Scientific Article
dc.publisherEmbo Press
dc.publisher.countryUnited Kingdomen_GB
dc.publisher.countryBritanniafi_FI
dc.publisher.country-codeGB
dc.relation.articlenumbere108863
dc.relation.doi10.15252/embj.2021108863
dc.relation.ispartofjournalEMBO Journal
dc.relation.volume40
dc.source.identifierhttps://www.utupub.fi/handle/10024/159427
dc.titleAutophagy in major human diseases
dc.year.issued2021

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