Association of Viral Load With Disease Severity in Outpatient Children With Respiratory Syncytial Virus Infection

Abstract

<p><em><strong>Background.</strong></em> There are scarce data on whether viral load affects the severity of respiratory syncytial virus (RSV) disease in outpatient children.<br></p><p><strong><em>Methods.</em> </strong>We analyzed the association between viral load and disease severity among children who participated in a prospective cohort study of respiratory infections. The children were examined and nasal swabs for the detection of RSV were obtained during each respiratory illness. Quantification of RSV load was based on the cycle threshold (Ct) value. For the primary analysis, the children were divided into 2 groups: higher (Ct < 27) and lower viral load (Ct >= 27).<br></p><p><em><strong>Results.</strong></em> Among 201 episodes of RSV infection, children with higher viral load had significantly longer median durations of rhinitis (8 vs 6 days; P = .0008), cough (8 vs 6 days; P = .034), fever (2 vs 1 days; P = .018), and any symptom (10 vs 8 days; P = .024) than those with lower viral load. There were statistically significant negative correlations between the Ct values and durations of all measured symptoms.<em><strong></strong></em><br></p><p><em><strong>Conclusions.</strong></em> Our findings support the concept that viral load drives the severity of RSV disease in children. Reducing the viral load by RSV antivirals might provide substantial benefits to outpatient children.</p>