GWAS and colocalization analyses implicate carotid intima-media thickness and carotid plaque loci in cardiovascular outcomes

Tietueen suppeat tiedot
dc.contributor.authorFranceschini N
dc.contributor.authorGiambartolomei C
dc.contributor.authorde Vries PS
dc.contributor.authorFinan C
dc.contributor.authorBis JC
dc.contributor.authorHuntley RP
dc.contributor.authorLovering RC
dc.contributor.authorTajuddin SM
dc.contributor.authorWinkler TW
dc.contributor.authorGraff M
dc.contributor.authorKavousi M
dc.contributor.authorDale C
dc.contributor.authorSmith AV
dc.contributor.authorHofer E
dc.contributor.authorvan Leeuwen EM
dc.contributor.authorNolte IM
dc.contributor.authorLu LY
dc.contributor.authorScholz M
dc.contributor.authorSargurupremraj M
dc.contributor.authorPitkanen N
dc.contributor.authorFranzen O
dc.contributor.authorJoshi PK
dc.contributor.authorNoordam R
dc.contributor.authorMarioni RE
dc.contributor.authorHwang SJ
dc.contributor.authorMusani SK
dc.contributor.authorSchminke U
dc.contributor.authorPalmas W
dc.contributor.authorIsaacs A
dc.contributor.authorCorrea A
dc.contributor.authorZonderman AB
dc.contributor.authorHofman A
dc.contributor.authorTeumer A
dc.contributor.authorCox AJ
dc.contributor.authorUitterlinden AG
dc.contributor.authorWong A
dc.contributor.authorSmit AJ
dc.contributor.authorNewman AB
dc.contributor.authorBritton A
dc.contributor.authorRuusalepp A
dc.contributor.authorSennblad B
dc.contributor.authorHedblad B
dc.contributor.authorPasaniuc B
dc.contributor.authorPenninx BW
dc.contributor.authorLangefeld CD
dc.contributor.authorWassel CL
dc.contributor.authorTzourio C
dc.contributor.authorFava C
dc.contributor.authorBaldassarre D
dc.contributor.authorO'Leary DH
dc.contributor.authorTeupser D
dc.contributor.authorKuh D
dc.contributor.authorTremoli E
dc.contributor.authorMannarino E
dc.contributor.authorGrossi E
dc.contributor.authorBoerwinkle E
dc.contributor.authorSchadt EE
dc.contributor.authorIngelsson E
dc.contributor.authorVeglia F
dc.contributor.authorRivadeneira F
dc.contributor.authorBeutner F
dc.contributor.authorChauhan G
dc.contributor.authorHeiss G
dc.contributor.authorSnieder H
dc.contributor.authorCampbell H
dc.contributor.authorVolzke H
dc.contributor.authorMarkus HS
dc.contributor.authorDeary IJ
dc.contributor.authorJukema JW
dc.contributor.authorde Graaf J
dc.contributor.authorPrice J
dc.contributor.authorPott J
dc.contributor.authorHopewell JC
dc.contributor.authorLiang JJ
dc.contributor.authorThiery J
dc.contributor.authorEngmann J
dc.contributor.authorGertow K
dc.contributor.authorRice K
dc.contributor.authorTaylor KD
dc.contributor.authorDhana K
dc.contributor.authorKiemeney LALM
dc.contributor.authorLind L
dc.contributor.authorRaffield LM
dc.contributor.authorLauner LJ
dc.contributor.authorHoldt LM
dc.contributor.authorDorr M
dc.contributor.authorDichgans M
dc.contributor.authorTraylor M
dc.contributor.authorSitzer M
dc.contributor.authorKumari M
dc.contributor.authorKivimaki M
dc.contributor.authorNalls MA
dc.contributor.authorMelander O
dc.contributor.authorRaitakari O
dc.contributor.authorFranco OH
dc.contributor.authorRueda-Ochoa OL
dc.contributor.authorRoussos P
dc.contributor.authorWhincup PH
dc.contributor.authorAmouyel P
dc.contributor.authorGiral P
dc.contributor.authorAnugu P
dc.contributor.authorWong Q
dc.contributor.authorMalik R
dc.contributor.authorRauramaa R
dc.contributor.authorBurkhardt R
dc.contributor.authorHardy R
dc.contributor.authorSchmidt R
dc.contributor.authorde Mutsert R
dc.contributor.authorMorris RW
dc.contributor.authorStrawbridge RJ
dc.contributor.authorWannamethee SG
dc.contributor.authorHagg S
dc.contributor.authorShah S
dc.contributor.authorMcLachlan S
dc.contributor.authorTrompet S
dc.contributor.authorSeshadri S
dc.contributor.authorKurl S
dc.contributor.authorHeckbert SR
dc.contributor.authorRing S
dc.contributor.authorHarris TB
dc.contributor.authorLehtimaki T
dc.contributor.authorGalesloot TE
dc.contributor.authorShah T
dc.contributor.authorde Faire U
dc.contributor.authorPlagnol V
dc.contributor.authorRosamond WD
dc.contributor.authorPost W
dc.contributor.authorZhu XF
dc.contributor.authorZhang XL
dc.contributor.authorGuo XQ
dc.contributor.authorSaba Y
dc.contributor.authorDehghan A
dc.contributor.authorSeldenrijk A
dc.contributor.authorMorrison AC
dc.contributor.authorHamsten A
dc.contributor.authorPsaty BM
dc.contributor.authorvan Duijn CM
dc.contributor.authorLawlor DA
dc.contributor.authorMook-Kanamori DO
dc.contributor.authorBowden DW
dc.contributor.authorSchmidt H
dc.contributor.authorWilson JF
dc.contributor.authorWilson JG
dc.contributor.authorRotter JI
dc.contributor.authorWardlaw JM
dc.contributor.authorDeanfield J
dc.contributor.authorHalcox J
dc.contributor.authorLyytikainen LP
dc.contributor.authorLoeffler M
dc.contributor.authorEvans MK
dc.contributor.authorDebette S
dc.contributor.authorHumphries SE
dc.contributor.authorVolker U
dc.contributor.authorGudnason V
dc.contributor.authorHingorani AD
dc.contributor.authorBjorkegren JLM
dc.contributor.authorCasas JP
dc.contributor.authorO'Donnell CJ
dc.contributor.authorHumphries SE
dc.contributor.authorVolker U
dc.contributor.authorGudnason V
dc.contributor.authorHingorani AD
dc.contributor.authorBjorkegren JLM
dc.contributor.authorCasas JP
dc.contributor.authorO'Donnell CJ
dc.contributor.organizationfi=sydäntutkimuskeskus|en=Cardiovascular Medicine (CAPC)|
dc.contributor.organizationfi=tyks, vsshp|en=tyks, varha|
dc.contributor.organization-code1.2.246.10.2458963.20.35734063924
dc.converis.publication-id37280526
dc.converis.urlhttps://research.utu.fi/converis/portal/Publication/37280526
dc.date.accessioned2022-10-28T13:50:42Z
dc.date.available2022-10-28T13:50:42Z
dc.description.abstractCarotid artery intima media thickness (cIMT) and carotid plaque are measures of subclinical atherosclerosis associated with ischemic stroke and coronary heart disease (CHD). Here, we undertake meta-analyses of genome-wide association studies (GWAS) in 71,128 individuals for cIMT, and 48,434 individuals for carotid plaque traits. We identify eight novel susceptibility loci for cIMT, one independent association at the previously-identified PINX1 locus, and one novel locus for carotid plaque. Colocalization analysis with nearby vascular expression quantitative loci (cis-eQTLs) derived from arterial wall and metabolic tissues obtained from patients with CHD identifies candidate genes at two potentially additional loci, ADAMTS9 and LOXL4. LD score regression reveals significant genetic correlations between cIMT and plaque traits, and both cIMT and plaque with CHD, any stroke subtype and ischemic stroke. Our study provides insights into genes and tissue-specific regulatory mechanisms linking atherosclerosis both to its functional genomic origins and its clinical consequences in humans.
dc.identifier.eissn2041-1723
dc.identifier.jour-issn2041-1723
dc.identifier.olddbid184694
dc.identifier.oldhandle10024/167788
dc.identifier.urihttps://www.utupub.fi/handle/11111/39470
dc.identifier.urnURN:NBN:fi-fe2021042720504
dc.language.isoen
dc.okm.affiliatedauthorKannisto, Niina
dc.okm.affiliatedauthorRaitakari, Olli
dc.okm.affiliatedauthorDataimport, tyks, vsshp
dc.okm.discipline3121 Internal medicineen_GB
dc.okm.discipline3121 Sisätauditfi_FI
dc.okm.internationalcopublicationinternational co-publication
dc.okm.internationalityInternational publication
dc.okm.typeA1 ScientificArticle
dc.publisherNATURE PUBLISHING GROUP
dc.publisher.countryUnited Kingdomen_GB
dc.publisher.countryBritanniafi_FI
dc.publisher.country-codeGB
dc.relation.articlenumberARTN 5141
dc.relation.doi10.1038/s41467-018-07340-5
dc.relation.ispartofjournalNature Communications
dc.relation.volume9
dc.source.identifierhttps://www.utupub.fi/handle/10024/167788
dc.titleGWAS and colocalization analyses implicate carotid intima-media thickness and carotid plaque loci in cardiovascular outcomes
dc.year.issued2018

Tiedostot

Näytetään 1 - 1 / 1
Name:
s41467-018-07340-5.pdf
Size:
1.63 MB
Format:
Adobe Portable Document Format
Description:
Publisher's PDF
Lataa

Kokoelmat

Rinnakkaistallenteet