Microparticle - based platform for point-of-care immunoassays

Toimittaja(t)

ACADEMIC PRESS INC ELSEVIER SCIENCE
Final draft
Microparticle - based platform for point-of-care immunoassays.pdf - 228.04 KB
Lataukset211

Pysyvä osoite

https://urn.fi/URN:NBN:fi-fe2021042719136

Verkkojulkaisu

DOI

10.1016/j.ab.2018.02.021

Tiivistelmä

There is a need for quantitative and sensitive, yet simple point-of-care immunoassays: We have developed a point-of-care microparticle-based immunoassay platform which combines the performance of a microliter well based assay with the usability of a rapid assay. The platform contained a separate reaction and detection chambers and microparticles for the solid-phase. Photoluminescent up-converting nanoparticles (UCNPs) were used as labels. The platform was tested with a cardiac troponin I assay, and a limit of detection of 19.7 ng/L was obtained. This study demonstrates the feasibility of developing point-of-care assays on the new platform for various analytes of interests.

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