Differential and shared genetic effects on kidney function between diabetic and non-diabetic individuals

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dc.contributor.authorWinkler Thomas W.
dc.contributor.authorRasheed Humaira
dc.contributor.authorTeumer Alexander
dc.contributor.authorGorski Mathias
dc.contributor.authorRowan Bryce X.
dc.contributor.authorStanzick Kira J.
dc.contributor.authorThomas Laurent F.
dc.contributor.authorTin Adrienne
dc.contributor.authorHoppmann Anselm
dc.contributor.authorChu Audrey Y.
dc.contributor.authorTayo Bamidele
dc.contributor.authorThio Chris H. L.
dc.contributor.authorCusi Daniele
dc.contributor.authorChai Jin-Fang
dc.contributor.authorSieber Karsten B.
dc.contributor.authorHorn Katrin
dc.contributor.authorLi Man
dc.contributor.authorScholz Markus
dc.contributor.authorCocca Massimiliano
dc.contributor.authorWuttke Matthias
dc.contributor.authorvan der Most Peter J.
dc.contributor.authorYang Qiong
dc.contributor.authorGhasemi Sahar
dc.contributor.authorNutile Teresa
dc.contributor.authorLi Yong
dc.contributor.authorPontali Giulia
dc.contributor.authorGünther Felix
dc.contributor.authorDehghan Abbas
dc.contributor.authorCorrea Adolfo
dc.contributor.authorParsa Afshin
dc.contributor.authorFeresin Agnese
dc.contributor.authorde Vries Aiko P. J.
dc.contributor.authorZonderman Alan B.
dc.contributor.authorSmith Albert V.
dc.contributor.authorOldehinkel Albertine J.
dc.contributor.authorDe Grandi Alessandro
dc.contributor.authorRosenkranz Alexander R.
dc.contributor.authorFranke Andre
dc.contributor.authorTeren Andrej
dc.contributor.authorMetspalu Andres
dc.contributor.authorHicks Andrew A.
dc.contributor.authorMorris Andrew P.
dc.contributor.authorTönjes Anke
dc.contributor.authorMorgan Anna
dc.contributor.authorPodgornaia Anna I.
dc.contributor.authorPeters Annette
dc.contributor.authorKörner Antje
dc.contributor.authorMahajan Anubha
dc.contributor.authorCampbell Archie
dc.contributor.authorFreedman Barry I.
dc.contributor.authorSpedicati Beatrice
dc.contributor.authorPonte Belen
dc.contributor.authorSchöttker Ben
dc.contributor.authorBrumpton Ben
dc.contributor.authorBanas Bernhard
dc.contributor.authorKrämer Bernhard K.
dc.contributor.authorJung Bettina
dc.contributor.authorÅsvold Bjørn Olav
dc.contributor.authorSmith Blair H.
dc.contributor.authorNing Boting
dc.contributor.authorPenninx Brenda W. J. H.
dc.contributor.authorVanderwerff Brett R.
dc.contributor.authorPsaty Bruce M.
dc.contributor.authorKammerer Candace M.
dc.contributor.authorLangefeld Carl D.
dc.contributor.authorHayward Caroline
dc.contributor.authorSpracklen Cassandra N.
dc.contributor.authorRobinson-Cohen Cassianne
dc.contributor.authorHartman Catharina A.
dc.contributor.authorLindgren Cecilia M.
dc.contributor.authorWang Chaolong
dc.contributor.authorSabanayagam Charumathi
dc.contributor.authorHeng Chew-Kiat
dc.contributor.authorLanzani Chiara
dc.contributor.authorKhor Chiea-Chuen
dc.contributor.authorCheng Ching-Yu
dc.contributor.authorFuchsberger Christian
dc.contributor.authorGieger Christian
dc.contributor.authorShaffer Christian M.
dc.contributor.authorSchulz Christina-Alexandra
dc.contributor.authorWiller Cristen J.
dc.contributor.authorChasman Daniel I.
dc.contributor.authorGudbjartsson Daniel F.
dc.contributor.authorRuggiero Daniela
dc.contributor.authorToniolo Daniela
dc.contributor.authorCzamara Darina
dc.contributor.authorPorteous David J.
dc.contributor.authorWaterworth Dawn M.
dc.contributor.authorMascalzoni Deborah
dc.contributor.authorMook-Kanamori Dennis O.
dc.contributor.authorReilly Dermot F.
dc.contributor.authorDaw E. Warwick
dc.contributor.authorHofer Edith
dc.contributor.authorBoerwinkle Eric
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dc.contributor.authorTai E-Shyong
dc.contributor.authorCatamo Eulalia
dc.contributor.authorRizzi Federica
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dc.contributor.authorRivadeneira Fernando
dc.contributor.authorGuilianini Franco
dc.contributor.authorSveinbjornsson Gardar
dc.contributor.authorEhret Georg
dc.contributor.authorWaeber Gerard
dc.contributor.authorBiino Ginevra
dc.contributor.authorGirotto Giorgia
dc.contributor.authorPistis Giorgio
dc.contributor.authorNadkarni Girish N.
dc.contributor.authorDelgado Graciela E.
dc.contributor.authorMontgomery Grant W.
dc.contributor.authorSnieder Harold
dc.contributor.authorCampbell Harry
dc.contributor.authorWhite Harvey D.
dc.contributor.authorGao He
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dc.contributor.authorSchmidt Helena
dc.contributor.authorLi Hengtong
dc.contributor.authorBrenner Hermann
dc.contributor.authorHolm Hilma
dc.contributor.authorKirsten Holgen
dc.contributor.authorKramer Holly
dc.contributor.authorRudan Igor
dc.contributor.authorNolte Ilja M.
dc.contributor.authorTzoulaki Ioanna
dc.contributor.authorOlafsson Isleifur
dc.contributor.authorMartins Jade
dc.contributor.authorCook James P.
dc.contributor.authorWilson James F.
dc.contributor.authorHalbritter Jan
dc.contributor.authorFelix Janine F.
dc.contributor.authorDivers Jasmin
dc.contributor.authorKooner Jaspal S.
dc.contributor.authorLee Jeannette Jen-Mai
dc.contributor.authorO’Connell Jeffrey
dc.contributor.authorRotter Jerome I.
dc.contributor.authorLiu Jianjun
dc.contributor.authorXu Jie
dc.contributor.authorThiery Joachim
dc.contributor.authorÄrnlöv Johan
dc.contributor.authorKuusisto Johanna
dc.contributor.authorJakobsdottir Johanna
dc.contributor.authorTremblay Johanne
dc.contributor.authorChambers John C.
dc.contributor.authorWhitfield John B.
dc.contributor.authorGaziano John M.
dc.contributor.authorMarten Jonathan
dc.contributor.authorCoresh Josef
dc.contributor.authorJonas Jost B.
dc.contributor.authorMychaleckyj Josyf C.
dc.contributor.authorChristensen Kaare
dc.contributor.authorEckardt Kai-Uwe
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dc.contributor.authorOrho-Melander Marju
dc.contributor.authorLaakso Markku
dc.contributor.authorLoeffler Markus
dc.contributor.authorPerola Markus
dc.contributor.authorde Borst Martin H.
dc.contributor.authorGögele Martin
dc.contributor.authorLa Bianca Martina
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dc.contributor.authorFeitosa Mary F.
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dc.contributor.authorWojczynski Mary K.
dc.contributor.authorKavousi Maryam
dc.contributor.authorKanai Masahiro
dc.contributor.authorAkiyama Masato
dc.contributor.authorYasuda Masayuki
dc.contributor.authorNauck Matthias
dc.contributor.authorWaldenberger Melanie
dc.contributor.authorChee Miao-Li
dc.contributor.authorChee Miao-Ling
dc.contributor.authorBoehnke Michael
dc.contributor.authorPreuss Michael H.
dc.contributor.authorStumvoll Michael
dc.contributor.authorProvince Michael A.
dc.contributor.authorEvans Michele K.
dc.contributor.authorO’Donoghue Michelle L.
dc.contributor.authorKubo Michiaki
dc.contributor.authorKähönen Mika
dc.contributor.authorKastarinen Mika
dc.contributor.authorNalls Mike A.
dc.contributor.authorKuokkanen Mikko
dc.contributor.authorGhanbari Mohsen
dc.contributor.authorBochud Murielle
dc.contributor.authorJosyula Navya Shilpa
dc.contributor.authorMartin Nicholas G.
dc.contributor.authorTan Nicholas Y. Q.
dc.contributor.authorPalmer Nicholette D.
dc.contributor.authorPirastu Nicola
dc.contributor.authorSchupf Nicole
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dc.contributor.authorHutri-Kähönen Nina
dc.contributor.authorMononen Nina
dc.contributor.authorBansal Nisha
dc.contributor.authorDevuyst Olivier
dc.contributor.authorMelander Olle
dc.contributor.authorRaitakari Olli T.
dc.contributor.authorPolasek Ozren
dc.contributor.authorManunta Paolo
dc.contributor.authorGasparini Paolo
dc.contributor.authorMishra Pashupati P.
dc.contributor.authorSulem Patrick
dc.contributor.authorMagnusson Patrik K. E.
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dc.contributor.authorBurkhardt Ralph
dc.contributor.authorTao Ran
dc.contributor.authorNoordam Raymond
dc.contributor.authorMägi Reedik
dc.contributor.authorSchmidt Reinhold
dc.contributor.authorde Mutsert Renée
dc.contributor.authorRueedi Rico
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dc.contributor.authorFelicita Sala Cinzia
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dc.contributor.authorPadmanabhan Sandosh
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dc.contributor.authorKerr Shona M.
dc.contributor.authorVaccargiu Simona
dc.contributor.authorPatil Snehal B.
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dc.contributor.authorBakker Stephan J. L.
dc.contributor.authorLim Su-Chi
dc.contributor.authorLucae Susanne
dc.contributor.authorVogelezang Suzanne
dc.contributor.authorBergmann Sven
dc.contributor.authorCorre Tanguy
dc.contributor.authorAhluwalia Tarunveer S.
dc.contributor.authorLehtimäki Terho
dc.contributor.authorBoutin Thibaud S.
dc.contributor.authorMeitinger Thomas
dc.contributor.authorWong Tien-Yin
dc.contributor.authorBergler Tobias
dc.contributor.authorRabelink Ton J.
dc.contributor.authorEsko Tõnu
dc.contributor.authorHaller Toomas
dc.contributor.authorThorsteinsdottir Unnur
dc.contributor.authorVölker Uwe
dc.contributor.authorFoo Valencia Hui Xian
dc.contributor.authorSalomaa Veikko
dc.contributor.authorVitart Veronique
dc.contributor.authorGiedraitis Vilmantas
dc.contributor.authorGudnason Vilmundur
dc.contributor.authorJaddoe Vincent W. V.
dc.contributor.authorHuang Wei
dc.contributor.authorZhang Weihua
dc.contributor.authorWei Wen Bin
dc.contributor.authorKiess Wieland
dc.contributor.authorMärz Winfried
dc.contributor.authorKoenig Wolfgang
dc.contributor.authorLieb Wolfgang
dc.contributor.authorGao Xin
dc.contributor.authorSim Xueling
dc.contributor.authorWang Ya Xing
dc.contributor.authorFriedlander Yechiel
dc.contributor.authorTham Yih-Chung
dc.contributor.authorKamatani Yoichiro
dc.contributor.authorOkada Yukinori
dc.contributor.authorMilaneschi Yuri
dc.contributor.authorYu Zhi
dc.contributor.authorLifelines cohort study
dc.contributor.authorDiscovEHR/MyCode study
dc.contributor.authorVA Million Veteran Program
dc.contributor.authorStark Klaus J.
dc.contributor.authorStefansson Kari
dc.contributor.authorBöger Carsten A.
dc.contributor.authorHung Adriana M.
dc.contributor.authorKronenberg Florian
dc.contributor.authorKöttgen Anna
dc.contributor.authorPattaro Cristian
dc.contributor.authorHeid Iris M.
dc.contributor.organizationfi=InFLAMES Lippulaiva|en=InFLAMES Flagship|
dc.contributor.organizationfi=sydäntutkimuskeskus|en=Cardiovascular Medicine (CAPC)|
dc.contributor.organizationfi=tyks, vsshp|en=tyks, varha|
dc.contributor.organizationfi=väestötutkimuskeskus|en=Centre for Population Health Research (POP Centre)|
dc.contributor.organization-code1.2.246.10.2458963.20.35734063924
dc.contributor.organization-code1.2.246.10.2458963.20.42471027641
dc.contributor.organization-code1.2.246.10.2458963.20.68445910604
dc.converis.publication-id176001886
dc.converis.urlhttps://research.utu.fi/converis/portal/Publication/176001886
dc.date.accessioned2022-10-27T12:16:54Z
dc.date.available2022-10-27T12:16:54Z
dc.description.abstract<p>A large-scale GWAS provides insight on diabetes-dependent genetic effects on the glomerular filtration rate, a common metric to monitor kidney health in disease.Reduced glomerular filtration rate (GFR) can progress to kidney failure. Risk factors include genetics and diabetes mellitus (DM), but little is known about their interaction. We conducted genome-wide association meta-analyses for estimated GFR based on serum creatinine (eGFR), separately for individuals with or without DM (n<sub>DM</sub> = 178,691, n<sub>noDM</sub> = 1,296,113). Our genome-wide searches identified (i) seven eGFR loci with significant DM/noDM-difference, (ii) four additional novel loci with suggestive difference and (iii) 28 further novel loci (including <i>CUBN</i>) by allowing for potential difference. GWAS on eGFR among DM individuals identified 2 known and 27 potentially responsible loci for diabetic kidney disease. Gene prioritization highlighted 18 genes that may inform reno-protective drug development. We highlight the existence of DM-only and noDM-only effects, which can inform about the target group, if respective genes are advanced as drug targets. Largely shared effects suggest that most drug interventions to alter eGFR should be effective in DM and noDM.<br></p>
dc.identifier.eissn2399-3642
dc.identifier.olddbid174424
dc.identifier.oldhandle10024/157518
dc.identifier.urihttps://www.utupub.fi/handle/11111/34266
dc.identifier.urlhttps://doi.org/10.1038/s42003-022-03448-z
dc.identifier.urnURN:NBN:fi-fe2022091258482
dc.language.isoen
dc.okm.affiliatedauthorRaitakari, Olli
dc.okm.affiliatedauthorDataimport, tyks, vsshp
dc.okm.discipline3121 Internal medicineen_GB
dc.okm.discipline3121 Sisätauditfi_FI
dc.okm.internationalcopublicationinternational co-publication
dc.okm.internationalityInternational publication
dc.okm.typeA1 ScientificArticle
dc.publisherNature
dc.publisher.countryUnited Statesen_GB
dc.publisher.countryYhdysvallat (USA)fi_FI
dc.publisher.country-codeUS
dc.relation.articlenumber580
dc.relation.doi10.1038/s42003-022-03448-z
dc.relation.ispartofjournalCommunications Biology
dc.relation.issue1
dc.relation.volume5
dc.source.identifierhttps://www.utupub.fi/handle/10024/157518
dc.titleDifferential and shared genetic effects on kidney function between diabetic and non-diabetic individuals
dc.year.issued2022

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