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LRG1 and SDR16C5 protein expressions differ according to HPV status in oropharyngeal squamous cell carcinoma
The increasing incidence of oropharyngeal squamous cell carcinoma (OPSCC) is primarily due to human papillomavirus, and understanding the tumor biology caused by the virus is crucial. Our goal was to investigate the proteins ... -
Integrating TSPO-PET imaging with metabolomics for enhanced prognostic accuracy in multiple sclerosis
<p><strong>Background </strong>Predicting disease progression in multiple sclerosis (MS) remains challenging. PET imaging with 18 kDa translocator protein (TSPO) radioligands can detect microglial and astrocyte activation ... -
Streptococcus salivarius Probiotics to Prevent Acute Otitis Media in Children: A Randomized Clinical Trial
<p>Importance <br>New approaches for the prevention of acute otitis media (AOM), the most common reason for antibiotic use in children, are needed.</p><p>Objective <br>To assess the efficacy of the Streptococcus salivarius ... -
Building Better Models: Benchmarking Feature Extraction and Matching for Structure from Motion at Construction Sites
The popularity of Structure from Motion (SfM) techniques has significantly advanced 3D reconstruction in various domains, including construction site mapping. Central to SfM, is the feature extraction and matching process, ... -
Genetic contribution to disease-course severity and progression in the SUPER-Finland study, a cohort of 10,403 individuals with psychotic disorders
Genetic factors contribute to the susceptibility of psychotic disorders, but less is known how they affect psychotic disease-course development. Utilizing polygenic scores (PGSs) in combination with longitudinal healthcare ... -
Encapsulated mitochondria to reprogram the metabolism of M2-type macrophages for anti-tumor therapy
<p>M2-type macrophages (M2Φ) play a pro-tumorigenic role and are closely associated with tumor development, where metabolic dysregulation exacerbates the immunosuppressive tumor microenvironment and fosters tumor growth. ... -
The STRING database in 2023: protein-protein association networks and functional enrichment analyses for any sequenced genome of interest
Much of the complexity within cells arises from functional and regulatory interactions among proteins. The core of these interactions is increasingly known, but novel interactions continue to be discovered, and the information ... -
Second Virtual International Symposium on Cellular and Organismal Stress Responses, September 8-9, 2022
The Second International Symposium on Cellular and Organismal Stress Responses took place virtually on September 8-9, 2022. This meeting was supported by the Cell Stress Society International (CSSI) and organized by Patricija ... -
The majority of type 2 diabetic patients in Finnish primary care are at very high risk of cardiovascular events: A cross-sectional chart review study (STONE HF)
<p>Aims<br></p><p>To characterize clinical profiles, prevalence of chronic kidney disease (CKD), and treatment patterns in type 2 diabetes (T2D) and heart failure (HF) patients in Finnish primary care.<br></p><p>Methods< ... -
Standard Deviation vs. Gini Coefficient: Effects of Different Indicators of Classroom Status Hierarchy on Bullying Behavior
<p>Classroom status hierarchy (the degree to which popularity is unequally distributed in a classroom) has often been examined as a predictor of bullying. Although most research has relied on an operationalization of status ... -
Anticipation and futures knowledge in policy and strategy-making at the local level in Finland
In this chapter, I study anticipation at the municipal level in Finland. Municipalities face rapid changes in their operational environment, which increases their willingness to govern the future. Municipal strategy is a ... -
An Automated Device for Recording Peripheral Arterial Waveform
Computing in Cardiology<p>The aim of the study was to develop an automated device for recording peripheral arterial pulse wave, in order to assess cardiovascular health. Recent studies have shown that photoplethysmography (PPG) is a viable ... -
Enhancing Toughness and Reducing Volumetric Shrinkage for Bis-GMA/TEGDMA Resin Systems by Using Hyperbranched Thiol Oligomer HMDI-6SH
<p>In order to improve the toughness and reduce polymerization shrinkage of traditional bisphenol A-glycidyl methacrylate (Bis-GMA)/triethylene glycol dimethacrylate (TEGDMA) based dental resin system, a hyperbranched thiol ... -
Infectious viruses from transfected SARS-CoV-2 genomic RNA
<p>SARS-CoV-2 emerged at the end of 2019, and like other novel pathogens causing severe symptoms, WHO recommended heightened biosafety measures for laboratories working with the virus. The positive-stranded genomic RNA of ... -
Short Physical Performance Battery and all-cause mortality: systematic review and meta-analysis
Background: The Short Physical Performance Battery (SPPB) is a well-established tool to assess lower extremity physical performance status. Its predictive ability for all-cause mortality has been sparsely reported, but ... -
Exploring care pathways of patients conveyed by emergency medical services (EMS) through electronic health records
<p><strong>Background: </strong>Emergency Medical Services (EMS) and Emergency Departments (ED) have reported increased patient volumes in the last decades. Despite high rates of non-conveyance decisions, unnecessary ... -
Temporal changes in the associations between diagnosed psychiatric disorders and dropping out of school early
Psychiatric problems are risk markers for poor educational attainment. The number of adolescents receiving treatment has increased. We investigated whether the association between psychiatric problems in early adolescence ...
