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Circulating CXCR5−PD-1hi peripheral T helper cells are associated with progression to type 1 diabetes
<p>Aims/hypothesis Type 1 diabetes is preceded by a period of asymptomatic autoimmunity characterised by positivity for islet autoantibodies. Therefore, T helper cell responses that induce B cell activation are likely to ... -
Stress urinary incontinence after hysterectomy: a 10-year national follow-up study
<p><strong>Purpose</strong>: Hysterectomy has been associated with increased risk for developing stress urinary incontinence (SUI) and having a SUI operation. We examined the long-term rate of SUI operations after hysterectomy ... -
Virtual clinical trials identify effective combination therapies in ovarian cancer
A major issue in oncology is the high failure rate of translating preclinical results in successful clinical trials. Using a virtual clinical trial simulations approach, we present a mathematical framework to estimate the ... -
Life-threatening bleeding after mastectomy and deliverance by a single suture: A case-report
Postoperative bleeding after mastectomy is rarely a life-threatening complication. However, it can be fatal without treatment, particularly in patients taking antithrombotic medications. We present a case of 84-year-old ... -
Oppimisympäristön turvallisuuden osa-alueet ja tilannekuva
<p>Dimensions of safety in learning environments and a timely snapshot – managing safety in basic education based on safety notice reports<br></p><p>Reporting safety deviations is a key indicator of safety culture in a ... -
Epigenetic inheritance of diet-induced and sperm-borne mitochondrial RNAs
Spermatozoa harbour a complex and environment-sensitive pool of small non-coding RNAs (sncRNAs)<sup>1</sup>, which influences offspring development and adult phenotypes<sup>1-7</sup>. Whether spermatozoa in the epididymis ... -
Effectiveness of workplace choice architecture modification for healthy eating and daily physical activity
<p><b>Background</b><br>Modifying the choice architecture of behavioural contexts can facilitate health behaviour change, but existing evidence builds mostly on small-scale interventions limited in duration, targets, ... -
How does Digitalisation Transform Business Models in Ropax Ports? A Multi-Site Study of Port Authorities
<p>This article investigates the relationship between digitalisation and business model changes in RoPax ports. The study is based on six RoPax ports in Northern Europe, examining their digitalisation efforts and the ... -
Adult-onset epilepsy and risk of traumatic brain injury: a nationwide cohort study
<p>Background <br></p><p>A knowledge gap exists regarding the risk of traumatic brain injury (TBI) in patients with epilepsy.</p><p>Methods <br></p><p>Patients with adult-onset epilepsy during 2005-2018 in Finland were ... -
“The Authors” Make Me Think Equally of Women and Men: Exploring Mixed-Gender Representations in a Visual Categorisation Task
<p>Abstract: A common goal for gender-fair language policies is to promote terms that elicit balanced activation of gender categories. Expanding previous research on the activation of feminine versus masculine categories ... -
Characterizing High-Energy Solar Proton Events with Energies Below and Above 100 MeV
We analyzed 58 high-energy proton events that occurred during the years 1996 – 2022. In 32 out of the 58 (55%) events, the proton energies extended up to ∼68 MeV but did not reach 100 MeV. In the remaining 26 events, the ... -
Parallel, Continuous Monitoring and Quantification of Programmed Cell Death in Plant Tissue
<p>Accurate quantification of hypersensitive response (HR) programmed cell death is imperative for understanding plant defense mechanisms and developing disease-resistant crop varieties. Here, a phenotyping platform for ... -
Viral DNA in submandibular gland tissue with an inflammatory disorder
<p>Background</p><p>The etiology behind different types of chronic sialadenitis (CS), some of which exhibit IgG4 overexpression, is unknown. Further, IgG4-related disease (IgG4-RD) commonly affects the submandibular gland, ... -
Identification of stemness-related glycosylation changes in head and neck squamous cell carcinoma
<p><b>Background:</b> Altered glycosylation is a hallmark of cancer associated with therapy resistance and tumor behavior. In this study, we investigated the glycosylation profile of stemness-related proteins OCT4, CIP2A, ... -
Plasma calprotectin is extremely high in patients with lysinuric protein intolerance
<p>Lysinuric protein intolerance (LPI) is a rare autosomal recessive disorder affecting the transport of cationic amino acids. Elevated plasma zinc concentrations have been described in patients with LPI. Calprotectin is ... -
Eudaimonia and temperance: A pathway to a flourishing life
Routledge Studies in Sustainable Development<p> <span>The concept of planetary well-being rests on the idea that since human activities are among the root causes of the ecological crisis threatening the well-being of human and nonhuman nature, accordingly, solutions ... -
Vihtori Kosolan nopea nousu ja tuho - Uusi elämäkerta piirtää kuvan onnettomasta ihmiskohtalosta ja murskaa myyttejä Lapuan liikkeestä (Kirja-arvio)
<p>Jukka-Pekka Pietiäisen kirjoittama elämäkerta on ensimmäinen tieteellinen kokonaisesitys Lapuan liikkeen johtajasta Vihtori Kosolasta (1884–1936). Elämäkerta piirtää kuvan maalaisliittolaistaustaisesta aktivistista, ... -
Uusmaterialismit ja taiteiden tutkimus: yhteismuotoutumista kartoittamassa
<p>In this article, we propose that the very formation of new materialisms as a concept and range of research practices has partly occurred with(in) the study of arts. In some significant ways, then, which warrant further ...
