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Rapid cleavage of 6-[18F]fluoronicotinic acid prosthetic group governs BT12 glioblastoma xenograft uptake: implications for radiolabeling design of biomolecules
<p><strong>Background: </strong>Peptides radiolabeled with fluorine-18 are frequently synthesized using prosthetic groups. Among them, activated esters of 6-[<sup>18</sup>F]fluoronicotinic acid ([<sup>18</sup>F]FNA) have ... -
Borrelia burgdorferi Infection in Biglycan Knockout Mice
<p>Background: Borrelia burgdorferi sensu lato spirochetes (Borrelia) causing Lyme borreliosis are able to disseminate from the initial entry site to distant organs in the host. Outer-surface adhesins are crucial in the ... -
Design thinking in early childhood education and care. A literature review and consideration from the perspective of young learners’ craft, design, and technology education
<p>Design thinking is a cognitive, iterative process that involves identifying goals, understanding users, and creating solutions. It has changed from a designers’ activity to an all-around approach to the innovation process ... -
Density functional theory and machine learning for electrochemical square-scheme prediction: an application to quinone-type molecules relevant to redox flow batteries
<p>Proton–electron transfer (PET) reactions are rather common in chemistry and crucial in energy storage applications. How electrons and protons are involved or which mechanism dominates is strongly molecule and pH dependent. ... -
Gender minorities and persons with disabilities defining their perpetrators at music festivals
<p>There are recent studies on sexual harassment at music festivals, particularly toward female attendees. However, studies on perpetrators of minority members are scarce. We wanted to discover the prevalence of inappropriate ... -
Cardiomyopathy associated with the Ala143Thr variant of the α-galactosidase A gene
<p>Objective </p><p>To investigate whether the Ala143Thr variant of the α-galactosidase A gene (A143T/GLA), with conflicting interpretations of pathogenicity, is associated with Fabry cardiomyopathy.</p><p>Methods </p><p>The ... -
Automated extrusion-based dispensing: Personalized dosing and quality control of clopidogrel tablets for pediatric care
The exploration of three-dimensional (3D) printing inspired technologies in pharmaceutical compounding reveals a promising frontier in personalized medicine manufacture. This study focuses on the development of clopidogrel ... -
Occupational Sex Segregation and its Consequences for the (Re-)Production of Gender Inequalities in the German Labour Market
Methodology of educational measurement and assessment<p>In Germany, the structuring principle connecting the educational system and the labour market is occupations. In theory, this occupational principle is gender-neutral, because both women and men are channelled into jobs ... -
Learning and teaching biological data science in the Bioconductor community
Modern biological research is increasingly data-intensive, leading to a growing demand for effective training in biological data science. In this article, we provide an overview of key resources and best practices available ... -
Weighted sieves with switching
<p>Weighted sieves are used to detect numbers with at most S prime factors with S∈N as small as possible. When one studies problems with two variables in somewhat symmetric roles (such as Chen primes, that is primes p ... -
A thousand words tell more than just numbers: Financial crises and historical headlines
<p>We show that financial crises are preceded by changes in specific types of narrative information contained in newspaper article titles. Our novel international dataset and the resulting empirical evidence are gathered ... -
Deep generative denoising networks enhance quality and accuracy of gated cardiac PET data
<p><strong>Background:</strong> Cardiac positron emission tomography (PET) can visualize and quantify the molecular and physiological pathways of cardiac function. However, cardiac and respiratory motion can introduce ... -
Different Relationship between hsp70 mRNA and hsp70 Levels in the Heat Shock Response of Two Salmonids with Dissimilar Temperature Preference
The heat shock response (HSR) refers to the rapid production of heat shock proteins (hsps) in response to a sudden increase in temperature. Its regulation by heat shock factors is a good example of how gene expression is ... -
X-ray polarimetry of X-ray pulsar X Persei: another orthogonal rotator?
<p> X Persei is a persistent low-luminosity X-ray pulsar of period of ≈ 835 s in a Be binary system. The field strength at the neutron star surface is not known precisely, but indirect signs indicate a magnetic field above ... -
Serum APOC1 levels are decreased in young autoantibody positive children who rapidly progress to type 1 diabetes
<p> Better understanding of the early events in the development of type 1 diabetes is needed to improve prediction and monitoring of the disease progression during the substantially heterogeneous presymptomatic period of ... -
Improved risk prediction of chemotherapy-induced neutropenia-model development and validation with real-world data
<p><strong>Background</strong> The existing risk prediction models for chemotherapy-induced febrile neutropenia (FN) do not necessarily apply to real-life patients in different healthcare systems and the external validation ... -
Neolithic land use in the northern Boreal zone: high-resolution multiproxy analyses from Lake Huhdasjarvi, south-eastern Finland
Two high-resolution pollen and charcoal analyses were constructed from sediments obtained from a small bay in eastern Finland in order to gain information on human activity during the Neolithic Stone Age, 5200-1800 BC. We ... -
Peatland pixel-level classification via multispectral, multiresolution and multisensor data using convolutional neural network
<p>High-resolution mapping of boreal peatlands is crucial for greenhouse gas inventories, ecological monitoring, and sustainable land management. However, accurately classifying peatland ecotypes at large scales remains ... -
Models, frameworks and theories in the implementation of programs targeted to reduce formal coercion in mental health settings: a systematic review
<p>Introduction: <br></p><p>Implementation models, frameworks and theories (hereafter tools) provide researchers and clinicians with an approach to understand the processes and mechanisms for the successful implementation ...
