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Metioniini 1-sidotun ubikitinaation rooli kolorektaalisyövän kehityksessä 3D-syöpäsolumalleissa
(2023-01-05)
Kolorektaalisyövällä viitataan ruuansulatuskanavan loppuosassa eli umpisuolessa, koolonissa tai peräsuolen alueella esiintyvään syöpään. Kolorektaalisyövän kehittymisessä perinnöllisyys on suuri riskitekijä, mutta esimerkiksi ...
Notch-ligandi Jagged1 suojaa DNA:n eheyttä
(2023-05-04)
Rintasyöpä on maailmanlaajuisesti naisten yleisin syöpätyyppi. Syövän tunnusmerkkejä ovat muun muassa kasvanut DNA-vaurioiden määrä sekä muutokset solujen normaalissa kasvussa ja ohjelmoidussa solukuolemassa. Osana ...
Expression, purification, and characterisation of a novel bacterial ADP-ribosyltransferase
(2023-05-24)
ADP-ribosylation is a chemical modification that is mostly known as a post-translational modification targeting nucleophilic amino acid residues. It utilizes the common coenzyme NAD+ as the reactant. The reaction is catalysed ...
Early detection of prostate cancer using extracellular vesicles and nanoparticle-aided time-resolved fluorescence immunoassay
(2023-06-28)
Prostate cancer (PCa) is a type of cancer that affects the prostate, an organ in the male
reproductive system. It is mostly diagnosed and deadliest cancers among men. In 2020,
approximately 1.4 million new cases were ...
Construction and functional validation of combinatorial designed ankyrin repeat protein (DARPin) libraries for phage display
(2023-05-29)
Designed ankyrin repeat protein (DARPin) is one of the most advanced alternative scaffold proteins. In this study, a combinatorial DARPin library for phage display was constructed. Firstly, a binary DARPin phage display ...
Discovery of novel antibiotics by metabolic engineering of Streptomyces soil bacteria
(2023-06-02)
Antimicrobial resistance is a rapidly developing threat that has been estimated to kill 10 million people yearly by 2050. This underscores the urgent need for novel antibiotics that do not share cross-resistance with ...
Supertehostajien säätelemät pitkät ei-koodaavat RNA:t ihon okasolusyövässä
(2023-05-19)
Ihon levyepiteelikarsinooma eli okasolusyöpä on keratinosyyttiperäinen syöpä, joka usein johtuu pitkittyneelle auringon UV-säteilylle altistumisesta. Pieni osa ihon okasolusyövistä metastasoi, eli muodostaa etäpesäkkeitä. ...
Transcriptional regulation in Spirochaeta africana
(2023-08-22)
The genome sets the limits of how far the cells can differentiate or adapt; the extent to which either actually happens is the territory of transcription. The molecular mechanisms of transcription are well known for E. ...
SENSORY CHARACTERIZATION OF COMMERCIAL PLANT-BASED MEAT ALTERNATIVES
(2023-06-27)
Consumers are increasingly interested in plant-based meat alternatives (PBMAs) as dietary protein sources, so the demand for products that closely mimic animal meat, especially in taste and texture, has grown. While few ...
Effect of yeast strains on the chemical composition of ciders from Finnish apple cultivars
(2024-01-02)
Effect of Saccharomyces and non- Saccharomyces yeast in apple ciders and juices were studied using Gas chromatography fitted with Flame Ionization Detector. Samples were produced from six different Finnish apple cultivars ...