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Aineistot 31-40 / 82
Inhibition of starch retrogradation by soluble soybean polysaccharides with different molecular weights and degrees of esterification
(2021-06-16)
Nowadays, cooked rice and noodles are the staple foods of many people, while they are difficult to be stored due to the high moisture content. Recently, a new polysaccharide-soluble soybean polysaccharide (SSPS), has been ...
Glycovariant-detecting proof-of-concept lectin-immunoassay development for pancreatic cancer diagnostics
(2021-09-01)
Pancreatic cancer (PaCa), a condition with a 9 % 5-year survival rate, is difficult to diagnose due to its unclear symptoms, but research has revealed changes in protein expression, extracellular vesicle formation and ...
Vimentiini ja ihmisen maitorauhasepiteelin mekanobiologinen säätely
(2021-05-31)
Vimentiini on välikokoinen säieproteiini, jota ilmentyy normaaleissa mesenkyymin soluissa, mutta myös maitorauhasen basaalisissa epiteelisoluissa. Rintasyöpäkasvaimissa vimentiinin määrä on normaalia korkeampi ja se on ...
Development of a rapid PCR-compatible, instrument-free and point-of-care applicable nucleic acid sample preparation method
(2021-06-21)
Molecular diagnostics and particularly polymerase chain reaction (PCR) assays have become a standard method of pathogen detection and disease diagnosis. They have boasted high sensitivity and specificity but been largely ...
Diagnostic performance of MUC1 glycovariant assay from ovarian cyst fluid
(2021-05-31)
Epithelial ovarian cancer (EOC) is the most lethal gynaecological malignancy. Mucins are heavily O-glycosylated proteins and used as serum biomarker for EOC. The conventional mucin-16 (also known as CA125) immunoassay ...
Omenan kypsyyden vaikutus Colletotrichumin aiheuttaman mätälaikkutaudin ilmenemiseen ja etenemiseen varastoidussa omenassa
(2022-12-05)
Colletotrichum on laaja sienisuku, johon kuuluu useita kasveille eri kasvitauteja aiheuttavia
mikrosieniä. Colletotrichum-sienisuku on yksi maataloudelle haitallisimmista sienisuvuista.
Omenan hedelmissä Colletotrichum-suvun ...
The impact of HSF1 or HSF2 knockdown on HSP90 inhibitor sensitivity in mammalian cells
(2023-03-06)
The heat shock response (HSR) induces the expression of the heat shock protein 90 (HSP90). HSP90 also maintains protein homeostasis by acting as a molecular chaperone. However, HSP90 is also known to be associated with ...
Oligonukleotidiraaka-aineen puhtauden optimointi Vanadis NIPT Assay analyysille
(2023-03-23)
Kromosomaalisten sairauksien seulonta on osa kansallisia raskaudenaikaisia tutkimuksia. Seulontojen tarkoitus on tunnistaa kromosomipoikkeavuudet sikiönkehityksen alkuvaiheessa, ja siten helpottaa hoitopäätösten tekoa. ...
Hormonal regulation of the osteogenic signature in bone metastatic Castration-Resistant Prostate Cancer (CRPC)
(2023-05-04)
Bone is the most preferred site for prostate cancer (PCa) metastasis which is a significant cause of cancer-related death in men. Bone metastasis in PCa typically forms sclerotic lesions, i.e., an increase in abnormal bone ...
Comparison of prime editing and base editing for generating the novel WRN R732P mutation in breast cancer cells
(2023-04-22)
Breast cancer is the most common cancer among women in Finland and worldwide, but, fortunately, the survival rate in Finland is over 90 %. Genome instability and mutations are one reason for the formation of cancer. WRN ...