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Effects of 27-hydroxycholesterol on oligodendrocytes in Alzheimer’s disease: a double-edged sword?
(2020-05-04)
Hypercholesterolemia is an established risk factor for developing Alzheimer’s disease (AD). A proposed link between elevated systemic cholesterol levels and AD is oxysterols: oxidized metabolites of cholesterol, which can ...
DNA repair genes in prostate cancer : the characterization of novel molecular mechanisms
(2020-05-18)
Prostate cancer is one of the major causes of cancer-related deaths in males in Western countries. Androgen deprivation therapy is a standard treatment for metastatic prostate cancer, aiming to suppress androgen receptor ...
Blocking Clever-1 on human monocytes inhibits the growth of aggressive breast cancer
(2019-07-31)
Immunosuppressive tumor microenvironment limits antitumoral immunity and facilitates cancer progression. Tumor-associated macrophages that are mainly derived from blood monocytes, are central regulators of the tumor immune ...
Reproductive analysis of HSD17B3 knockout mice
(2019-01-08)
Hydroxysteroid (17β) dehydrogenase type 3 (HSD17B3) is known to be the primary enzyme responsible for the conversion of androstenedione to testosterone in testes, and thus important for male sexual development, maturation ...
Identification of RasGEFs counteracting neuronal SynGAP1 function
(2021-05-11)
SynGAP syndrome refers to an under-diagnosed group of diseases caused by the mutation of the SynGAP1 gene encoding the predominant synaptic protein SynGAP1. SynGAP1 is a Ras GTPase activating protein that is a major regulator ...
In Search of Ebola Virus Glycoprotein Inhibitors: A Structure-Based Drug Design Study
(2021-03-05)
Ebola virus (EBOV) is one of the deadliest viruses that causes haemorrhagic fever in humans and the fatality rate is more than 50%. The biggest outbreak of Ebola virus disease (EVD) occurred in 2014-2016 in West Africa ...
Exercise-induced mobilization of white blood cells in breast cancer patients
(2023-04-24)
Acute exercise causes mobilization of the immune cells in healthy individuals, but the phenomenon is less investigated in cancer patients. Exercise-induced mobilization of leukocytes may have positive effects in cancer ...
The role of heat shock factor 2 during Epstein-Barr virus infection
(2023-05-09)
Epstein-Barr virus (EBV) infects over 90% of the world’s population. It establishes lifelong latent infections in its host. While most individuals are infected during childhood, and the infections remain mild or asymptomatic, ...
In Vitro Drug Screening of Cell Culture Models for LMNA-Related Dilated Cardiomyopathy
(2023-05-11)
Mutations in the LMNA gene encoding lamins A and C cause inherited diseases commonly called
laminopathies. The most common laminopathy is dilated cardiomyopathy (DCM) and currently, there
are no specific treatments for ...
Keratin 8 and hemidesmosomes – roles in colorectal cancer growth and mechanotransduction
(2023-01-16)
Keratins (Ks) are intermediate filament proteins that form a part of the cytoskeleton in intestinal epithelial cells. They provide the cells mechanical resilience against stresses caused by smooth muscle movements and ...