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Oral peptides: Mesoporous silicon loaded ionic liquids and trypsin inhibitors to promote oral absorption of semaglutide
(2023-05-22)
Ionic liquids (ILs), as solvents, permeation enhancers, and stabilizers of drugs, has achieved some success in the field of oral delivery of insoluble drugs. However, ILs still face different challenges in the oral delivery ...
Development of Complaint Monitoring Method for Levonorgestrel Intrauterine System Products
(2023-06-30)
The central purpose of quality and risk management in pharmaceutical industry is to protect the safety
of the population using the medicinal products. Complaint management is essential part of quality and
risk management ...
The Role of TIMP-1 in the Regulation of Melanoma Growth and Immune Response Control : The Role of TIMP-1 in Melanoma Progression
(2023-08-11)
TIMP-1 has recently emerged as a cytokine that mediates effects in immune cells. It is involved in proinflammatory conditions and is considered a poor prognosticator in many cancer types. However, its part in melanoma ...
Immunosuppressive effects of MERTK in macrophages and cancer cells
(2023-06-27)
Tumor-associated macrophages are an important factor regulating the tumor microenvironment due to their capability of removing apoptotic cancer cells. Tumor-associated macrophages are typically classified as anti-inflammatory ...
An in vitro model of hepatic steatosis and lipotoxicity – a focus on mitochondrial dysfunction and redox state
(2023-05-26)
Non-alcoholic fatty liver disease (NAFLD) and alcohol-related fatty liver disease (ALD) have emerged as the leading causes of chronic liver disease worldwide. They cover a range of conditions from hepatic steatosis to ...
Investigating filopodia formation on fibronectin and cadherin substrates
(2023-08-03)
Cancer metastasis involves cancer cells migrating from primary tumours to distant organs and tissues. Filopodia, slender finger-like protrusions, play a pivotal role in cell migration and interactions with the extracellular ...
Genetic Polymorphisms in TLR2, TLR4, IL-10, and IL-17A: Possible Effect on Pertussis Acellular Vaccine Response
(2023-08-08)
Pertussis, a highly infectious respiratory disease caused by Bordetella pertussis, is still endemic despite primary vaccination rates of 81% in 2021. Variability toward vaccination response due to genetic polymorphisms has ...
[18F]FDG PET/CT imaging for evaluating associations between glycolytic activity of brown adipose tissue, breast cancer progression and cachexia in a xenograft model
(2023-09-07)
BACKGROUND Brown adipose tissue (BAT) is a thermogenetic organ that helps to regulate body temperature. Besides the normal biological function of BAT, a relationship between BAT activity, cancer progression and cachexia ...
A Framework for the Systematic Comparison of Classical Non-Learning, Machine Learning, and Artificial Intelligence Approaches to Cell Segmentation & Nuclei Detection in Histopathological Images
(2023-08-03)
In the fields of diagnosis, digital pathology, and drug discovery, the characterization of tissue, in particular the cells, is crucial because it provides a fundamental understanding of the underlying cellular dynamics and ...
Ex vivo characterization of joint innervating neurons in osteoarthritic rodent pain model
(2023-08-28)
Osteoarthritis (OA) is the most common joint disease worldwide, affecting an estimate of 240 million people. The predominant symptom of OA is pain. Pain perception arises from nociceptive signals in the periphery, that ...