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Characterization of the novel solute carrier 26A7 gene and its impact on thyroid cell function
(2019-10-10)
Thyroid hormones (THs) are essential for normal growth and development. Insufficient production of THs at birth leads to congenital hypothyroidism (CH) affecting approximately 1:3000 newborns worldwide. The etiology of CH ...
Farmakokineettisten geenimuunnosten vaikutus liitännäislääkehoitona annetun dosetakselin aiheuttaman neutropenian riskiin ja hoidon tehoon suomalaisilla rintasyöpään sairastuneilla naisilla
(2018-10-04)
Rintasyöpä on naisten yleisin syöpätyyppi ja Suomessa siihen sairastui vuonna 2015 yli 5000 naista. Suuri osa rintasyöpään sairastuneista saa leikkauksen jälkeen riskiarvion mukaan liitännäishoitona lääke- tai/ ja sädehoitoa. ...
MicroRNA-107 Regulates Adiponectin Expression and Human Adipocyte Differentiation
(2019-05-14)
Adiponectin (AdipoQ) is a major adipokine with insulin-sensitizing and anti-inflammatory effects. AdipoQ expression is downregulated in obesity, insulin resistance and type 2 diabetes. In this study, we investigated the ...
The Antigen Processing Pathway in B Cells Utilizes Peripheral Endocytic Recycling Compartments
(2019-10-24)
B cells are responsible for the humoral responses of the adaptive immune system. B cells also act as antigen presenting cells: they internalize protein antigens and process them into peptides for presentation on Major ...
Interaction of silica with human immune cells
(2018-12-18)
Aim of this study was to evaluate silica’s ability to promote inflammation. Amorphous silica could be used in sustained drug delivery systems, but it needs to be proven to be safe.
Neutrophils ability to phagocytose ...
Functional characterization of a humanized anti-Clever-1 antibody targeting monocytes and anti-inflammatory macrophages
(2018-11-29)
Targeting the immunosuppressive tumor microenvironment has gained interest in opening new avenues to fight against cancer growth. Macrophages are extremely potential candidates for targeted therapies due to their highly ...
Protein-encapsulated in mesoporous silica nanoparticles for the the treatment of bacterial biofilms
(2019-05-13)
80% of infections are estimated to be biofilm related, which are extremely resistant to anti-microbials. It remains an unmet need to develop medications to treat biofilms. Currently, there are evolving approaches that use ...
Changes in norepinephrine transporter expression in models of Alzheimer´s disease
(2020-05-11)
Alzheimer´s disease (AD) is the most common form of dementia. AD can be associated with malfunction of the brain norepinephrine transporter (NET) and degeneration in the locus coeruleus (LC) which will reduce norepinephrine ...
Cell signaling in breast cancer associated with neurofibromatosis type 1
(2020-04-30)
Neurofibromatosis 1 (NF1) is an autosomal dominant disorder caused by mutations in the NF1 gene, which codes tumor suppressor protein neurofibromin. The incidence of NF1 is approximately 1:2000. Patients with NF1 are at ...
Intracellular metabolism and transport of paclitaxel in ovarian cancer
(2020-04-30)
Although traditional chemotherapies are still the backbone of ovarian cancer treatment, interpatient variability in drug response and acquired resistance still present a major hurdle. The antimitotic agent, paclitaxel, is ...