Hae
Aineistot 1-10 / 27
Preclinical evaluation of novel radiopharmaceuticals for positron emission tomography imaging of animal models of multiple sclerosis
(Turun yliopisto, 2020-11-06)
Multiple sclerosis (MS) is the most common autoimmune disease of central nervous system (CNS) that causes chronic neurological impairment and clinical disability. Neuroinflammation is a major element in MS pathology and ...
Brown and white adipose tissue metabolism in obesity: stimulation by cold and meal ingestion
(Turun yliopisto, 2022-05-21)
Adipose tissue (AT) metabolism is dysregulated in obesity. Reduced brown adipose tissue (BAT) glucose uptake during cold exposure is associated with obesity and insulin resistance, but the role of fatty acids in human BAT ...
Adipose tissue and brain metabolic adaptations to sprint interval training and moder-ate-intensity continuous training; studies in healthy and insulin resistant subjects.
(Turun yliopisto, 2018-06-15)
Abstract:
Background: Insulin resistance (IR) is associated with metabolic disturbances in several tissues, including increased insulin-stimulated glucose uptake in brain, decreased glucose uptake in adipose tissue and ...
Translocator protein as a biomarker in head and neck cancer
(Turun yliopisto, 2025-04-04)
Head and neck squamous cell carcinoma (HNSCC) consists of heterogeneous tumours originating from the head and neck region. Although advances in the treatment of HNSCC have been made during the last decade, cancer recurrence ...
Oxidative metabolism and non-invasive characterisation of brown adipose tissue in adult humans
(Turun yliopisto, 2018-04-28)
In adult humans, brown adipose tissue (BAT) has been found to be metabolically active. However, the physiological relevance of BAT in adult humans is still imprecise and largely speculative. The study of oxidative metabolism ...
Molecular imaging of autoimmune myocarditis using new PET tracers in experimental models
(Turun yliopisto, 2025-01-10)
Diagnosis of myocarditis is challenging because of non-specific clinical presentation of the disease. 18F-FDG PET/CT detects cardiac inflammation. However, non-specific physiological myocardial 18F-FDG uptake impairs the ...
Novel PET imaging approaches for neurodegenerative disease progression
(Turun yliopisto, 2025-02-28)
Neuropathic pain (NPP) and neonatal hypoxic–ischaemic encephalopathy (HIE) both have a limited understanding of neurological damage onset and progression, hampering the development of novel treatments. This thesis evaluated ...
Dual gated PET/CT imaging of heart
(Turun yliopisto, 2021-11-13)
Coronary artery disease (CAD) resulting from atherosclerotic arterial changes, plaques, is a progressive process, which can be asymptomatic for many years. Asymptomatic CAD can cause a heart attack that leads to sudden ...
Preclinical development of radiopharmaceuticals for Alzheimer’s disease: Biological evaluation of (S)-[18F]THK5117 and [11C]SMW139 PET tracers in the APP/PS1-21 mouse model of Alzheimer’s disease
(Turun yliopisto, 2024-02-27)
Alzheimer’s disease (AD) pathological cascade is characterised by the formation of β-amyloid peptide (Aβ) plaques and neurofibrillary tangles of hyperphosphorylated tau (p-tau) in association with neuroinflammation. Positron ...
Imaging glucose metabolism, neuroinflammation, and cannabinoid receptor 1 in transgenic mouse models of Alzheimer’s disease
(Turun yliopisto, 2019-04-13)
The pathophysiological cascade leading to Alzheimer’s disease is characterized by the accumulation of destructive β-amyloid in the brain. Convincing evidence has also shown that cerebral energy hypometabolism and an ...