Viimeksi syötetyt Väitöskirjat
Aineistot 281-300 / 2960
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Convergence of RAS and PP2A activities on chromatin repressor complexes
Turun yliopiston julkaisuja - Annales Universitatis Turkuensis D: Medica - Odontologica : 1778 (Turun yliopisto, 22.03.2024)Protein Phosphatase 2A (PP2A) is a serine-threonine phosphatase and, through its de-phosphorylation activity, mostly downregulates signaling pathways, while RAS belongs to the family of small GTPase and activates various ... -
Understanding the structure and meaning of Finnish texts: From corpus creation to deep language modelling
Turun yliopiston julkaisuja - Annales Universitatis Turkuensis F: Technica & Informatica : 35 (Turun yliopisto, 15.03.2024)Natural Language Processing (NLP) is a cross-disciplinary field combining elements of computer science, artificial intelligence, and linguistics, with the objective of developing means for computational analysis, understanding ... -
Androgen receptor therapy resistance in prostate cancer: From the disease model to the mechanisms
Turun yliopiston julkaisuja - Annales Universitatis Turkuensis, Ser D: Medica - Odontologica : 1782 (Turun yliopisto, 08.03.2024)Androgens act through the androgen receptor (AR) and are critical regulators of prostate differentiation and function, as well as prostate cancer (PCa) growth and survival. The development of treatment resistance in ... -
Clinical efficacy of platelet-rich plasma injections in common musculoskeletal disorders
Turun yliopiston julkaisuja - Annales Universitatis Turkuensis, Ser D: Medica - Odontologica : 777 (Turun yliopisto, 08.03.2024)Together osteoarthritis (OA) of the knee, epicondylitis of the elbow and tendinopathy of the shoulder rotator cuff (RC) affect 5.9% to 13.8% of the general population worldwide. These conditions cause significant disability ... -
Preclinical development of radiopharmaceuticals for Alzheimer’s disease: Biological evaluation of (S)-[18F]THK5117 and [11C]SMW139 PET tracers in the APP/PS1-21 mouse model of Alzheimer’s disease
Turun yliopiston julkaisuja - Annales Universitatis Turkuensis, Ser D: Medica - Odontologica : 1774 (Turun yliopisto, 27.02.2024)Alzheimer’s disease (AD) pathological cascade is characterised by the formation of β-amyloid peptide (Aβ) plaques and neurofibrillary tangles of hyperphosphorylated tau (p-tau) in association with neuroinflammation. Positron ... -
How play moves us: Toys, technologies, and mobility in a digital world
Turun yliopiston julkaisuja - Annales Universitatis Turkuensis B: Humaniora : 658 (Turun yliopisto, 02.03.2024)The 21st century has been described as the Century of Play. The change in current play is particularly noticeable when looking at technological developments. This thesis deals with the technologization, digitalization, and ... -
Erityiseksi määritellyn lapsen vaikuttajuuden toteutumisen mahdollistava hoitotyö: Lasten kuntoutushoitotyön dialoginen malli
Turun yliopiston julkaisuja - Annales Universitatis Turkuensis, Ser D: Medica - Odontologica : 1779 (Turun yliopisto, 22.03.2024)Tämän tutkimuksen tarkoituksena oli kehittää kehityksen variaatioiden perusteella erityiseksi määriteltyjen lasten vaikuttajuuden toteutumista mahdollistavan kuntoutushoitotyön malli empiirisen ja teoreettisen aineiston ... -
Impact of Lipid Structure and Selected Antioxidants on the Oxidation of Docosahexaenoic Acid
(Turun yliopisto, 08.03.2024)Docosahexaenoic acid (DHA; 22:6-n3, 4Z,7Z,10Z,13Z,16Z,19Z) is a long-chain polyunsaturated omega-3 fatty acid with several health benefits. It promotes cardiovascular health and is considered essential for the normal neural ... -
Assessment of disease activity of inflammatory bowel disease using positron emission tomography / magnetic resonance imaging and keratin 7 -analysis
Turun yliopiston julkaisuja - Annales Universitatis Turkuensis D: Medica - Odontologica : 1772 (Turun yliopisto, 08.03.2024)The clinical course of inflammatory bowel disease (IBD) is characterized by relapses and spontaneous or drug-induced remissions, but it cannot be predicted by currently known parameters. The priority of this thesis was to ... -
Follow-up of head and neck cancer patients after treatment
Turun yliopiston julkaisuja - Annales Universitatis Turkuensis D: Medica - Odontologica : 1775 (Turun yliopisto, 01.03.2024)Post-treatment follow-up of head and neck cancer patients is crucial due to their high risk of disease recurrence and increased likelihood of developing secondary cancers. Rehabilitation requires multiple visits to different ... -
Lifestyle habits and novel means for dietary screening and health promotion in pregnant women and children
Turun yliopiston julkaisuja - Annales Universitatis Turkuensis D: Medica - Odontologica : 1773 (Turun yliopisto, 01.03.2024)Lifestyle habits, including diet and physical activity, that deviate from the recommendations during pregnancy and early childhood may eventually increase the risk for obesity and other lifestyle-related diseases in both ... -
Cantilever enhanced photoacoustic spectroscopy: The First two decades
Turun yliopiston julkaisuja - Annales Universitatis Turkuensis AI: Astronomica, Chemica, Mathematica : 706 (Turun yliopisto, 29.02.2024)Two decades ago, the first experiments with a novel optical microphone using a small silicon cantilever as its sensing element were conducted at the University of Turku. In retrospect, those experiments revealed the potential ... -
Metformin versus insulin in gestational diabetes – long-term effects on child at the age of 9 years
Turun yliopiston julkaisuja - Annales Universitatis Turkuensis D: Medica - Odontologica : 1776 (Turun yliopisto, 08.03.2024)Gestational diabetes (GDM) is defined as a condition in which hyperglycaemia develops for the first time during pregnancy. Blood glucose-lowering pharmacological treatment is begun if, despite lifestyle changes, the blood ... -
Monitoring cellular Guanosine triphosphate (GTP) and GTP associated proteins
Turun yliopiston julkaisuja - Annales Universitatis Turkuensis AI: Astronomica, Chemica, Mathematica : 707 (Turun yliopisto, 01.03.2024)Guanosine-5'-triphosphate (GTP) is an essential molecule for cell survival and function. Although free GTP plays a crucial role in several cellular processes, most studies focus solely on the protein bound GTP and its ... -
Publicness of public space in the contemporary city: Insights from Helsinki, Finland
Turun yliopiston julkaisuja - Annales Universitatis Turkuensis B: Humaniora : 657 (Turun yliopisto, 01.03.2024)This dissertation studies the publicness of Narinkka Square, Tennispalatsi Square and Kamppi Shopping Centre, which are three publicly usable spaces located adjacent to one another in the Kamppi area of Helsinki, Finland. ... -
Complexities of competence: A study on Finnish upper-secondary school students' lexical development and use of L2 English. A mixed-methods examination
Turun yliopiston julkaisuja - Annales Universitatis Turkuensis B: Humaniora : 655 (Turun yliopisto, 17.02.2024)The dissertation examines Finnish upper-secondary school second language use from four perspectives: the development of lexical knowledge in relation to extramural activities (Article I); the role of lexical recognition ... -
Metabolism, Morphology, and Effect of Fat Grafts - Studies on Fat Graft Browning and Therapeutic Use in the Prevention of Peritoneal Adhesions
Turun yliopiston julkaisuja - Annales Universitatis Turkuensis, Ser D: Medica - Odontologica : 1771 (Turun yliopisto, 09.02.2024)BACKGROUND: Fat transfer is a basic technique in the field of plastic surgery, but so far, there is very little information about what happens to fat grafts after transfer. The aim of this dissertation was to determine ... -
Effectiveness of adults’ targeted interventions in stopping bullying
Turun yliopiston julkaisuja - Annales Universitatis Turkuensis B: Humaniora : 654 (Turun yliopisto, 02.02.2024)Teachers and other school personnel have the responsibility to intervene quickly when a case of bullying comes to their attention. However, previous research has mainly focused on evaluating whole-school prevention programs, ... -
Host genetic factors and human papillomavirus transmission and infection outcomes among family members
Turun yliopiston julkaisuja - Annales Universitatis Turkuensis, Ser D: Medica - Odontologica : 1770 (Turun yliopisto, 19.02.2024)The natural history of human papillomavirus (HPV) infections is complex, and more information is greatly needed to identify the host genetic and immunological factors that contribute to the infection susceptibility and its ... -
The molecular mechanisms of rapid thermal adaptation in European grayling
Turun yliopiston julkaisuja - Annales Universitatis Turkuensis A II: Biologica, Geographica, Geologica : 406 (Turun yliopisto, 09.02.2024)Adaptation is a key evolutionary process which may be important to maintain population viability during rapid environmental changes. The European grayling (Thymallus thymallus) is a freshwater salmonid that effectively ...
