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Seasonal variation in the brain μ-opioid receptor availability
<p>Seasonal rhythms influence emotion and sociability. The brain μ-opioid receptor (MOR) system modulates a multitude of seasonally varying socioemotional functions, but its seasonal variation remains elusive with no ...
Protein synthesis is suppressed in sporadic and familial Parkinson's disease by LRRK2
Gain of function LRRK2-G2019S is the most frequent mutation found in familial and sporadic Parkinson's disease. It is expected therefore that understanding the cellular function of LRRK2 will provide insight on the ...
Rates and age trends in lumbar fusions in 2002 – 2017 – a descriptive analysis of 3,000 patients
<p>Objective</p><p>The objective of this study was to describe the change in rates and age averages among patients undergoing lumbar fusion during the last 20 years in a university hospital district located in Finland.</p><p>Methods</p><p>The data on 3,066 fusion surgeries were obtained from an electronic register between 2002 – 2017. The t-test, chi square, and regression analyses were used.</p><p>Results</p><p>In 2002 – 2017, 3,066 patients underwent lumbar fusion. The annual fusion rates grew in 16 years by 500%. The regression coefficient for annual rates of lumbar fusion procedures was 17.4 (95% CI 14.8 to 20.0, p-value <0.0001) procedure/year. In general, the patients were becoming older over time with regression coefficient 0.67 (95% CI 0.55 to 0.78, p-value <0.0001, R20.04) year/year.</p><p>Conclusions</p><p>In the studied cohort, the annual rates of lumbar fusions grew explosively during the last 16 years by 500% and the patients were 10 years older in 2017 than back in 2002. It seems, that if the trend observed here will continue then fusion patients may on average be even 20 years older in 2030 than they were in 2002. Surgeons and policy makers should take this probability under consideration when planning future techniques, rehabilitation, and allocation of funding.</p>...
Brain death and postmortem organ donation: report of a questionnaire from the CENTER-TBI study
<h4>BACKGROUND: </h4><p>We aimed to investigate the extent of the agreement on practices around brain death and postmortem organ donation.</p><h4>METHODS: </h4><p>Investigators from 67 Collaborative European NeuroTrauma ...
High angular resolution diffusion-weighted imaging in mild traumatic brain injury
We sought to investigate white matter abnormalities in mild traumatic brain injury (mTBI) using diffusion-weighted magnetic resonance imaging (DW-MRI). We applied a global approach based on tract-based spatial statistics ...
Regional brain morphometry in patients with traumatic brain injury based on acute- and chronic-phase magnetic resonance imaging
Traumatic brain injury (TBI) is caused by a sudden external force and can be very heterogeneous in its manifestation. In this work, we analyse T1-weighted magnetic resonance (MR) brain images that were prospectively acquired ...
Somatostatin receptor 2A in gliomas: Association with oligodendrogliomas and favourable outcome
Somatostatin receptor subtype 2A (SSTR2A) is a potential therapeutic target in gliomas. Data on SSTR2A expression in different glioma entities, however, is particularly conflicting. Our objective was to characterize SSTR2A ...
Withdrawal from long-term use of zopiclone, zolpidem and temazepam may improve perceived sleep and quality of life in older adults with primary insomnia
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</p><p><i>Abstract:</i> Long-term use of benzodiazepine agonists is
widespread, although guidelines recommend short-term use. Only few controlled
studies have characterized the effect of discontinuation of their ...
Psychiatric (Axis I) and personality (Axis II) disorders and subjective psychiatric symptoms in chronic tinnitus
<p>Objective: Chronic tinnitus has been associated with several psychiatric disorders. Only few studies have investigated these disorders using validated diagnostic interviews. The aims were to diagnose psychiatric and ...