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Seasonal variation in the brain μ-opioid receptor availability
<p>Seasonal rhythms influence emotion and sociability. The brain μ-opioid receptor (MOR) system modulates a multitude of seasonally varying socioemotional functions, but its seasonal variation remains elusive with no ...
Brain amyloid load and its associations with cognition and vascular risk factors in FINGER study
To investigate brain amyloid pathology in a dementia-risk population defined as cardiovascular risk factors, aging, and dementia risk (CAIDE) score of at least 6 but with normal cognition and to examine associations between ...
Visual versus automated analysis of [I-123]FP-CIT SPECT scans in parkinsonism
The clinical evaluation of dopamine transporter (DAT) SPECT scans typically relies on visual analysis in combination with an automated semi-quantitative method. The interpretation of the results may be difficult in cases ...
Folate receptor-targeted positron emission tomography of experimental autoimmune encephalomyelitis in rats
<h2>Abstract</h2><div><p>BACKGROUND: Folate receptor-β (FR-β) is a cell surface receptor that is significantly upregulated on activated macrophages during inflammation and provides a potential target for folate-based ...
Efficacy and tolerability of folate-aminopterin therapy in a rat focal model of multiple sclerosis
BackgroundActivated macrophages in the experimental model of multiple sclerosis (MS) express folate receptor-beta (FR-beta), representing a promising target for the treatment of MS. Here, we both evaluated the efficacy of ...