Selaus tekijän mukaan kokoelmassa Rinnakkaistallenteet
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Epigenome-wide association study of serum urate reveals insights into urate co-regulation and the SLC2A9 locus
Milani Lili; März Winfried; Wolffenbuttel Bruce H. R.; Kasela Silva; Hemani Gibran; Hwang Shih-Jen; Völker Uwe; Mishra Pashupati P.; Chaker Layal; Henneman Peter; Waldenberger Melanie; Smith Jennifer A.; Herder Christian; Koenig Wolfgang; Baccarelli Andrea; Matias-Garcia Pamela R.; Kooner Jaspal S.; Thio Chris H. L.; Liu Dan; Stringhini Silvia; Breteler Monique M. B.; Bochud Murielle; Ghanbari Mohsen; Tin Adrienne; Köttgen Anna; Fraszczyk Eliza; Gelber Allan C.; Corre Tanguy; Yu Zhi; Venema Andrea; Kardia Sharon L. R.; Woodward Owen M.; van Vliet-Ostaptchouk Jana V.; Greenland Philip; Liu Hongo; Sundström Johan; Loh Marie; Weihs Antoine; Aziz Nasir A.; Nauck Matthias; Harris Sarah E.; Levy Daniel; Raitakari Olli T.; Schöttker Ben; Kleber Marcus E.; Winkelmann Juliane; Brenner Hermann; Endlich Karlhans; Min Josine L.; Susztak Katalin; Stocker Hannah R.; Floyd James S.; Bressler Jan; Kuhns Victoria L. Halperin; Gao Xu; Lu Ake T.; Teumer Alexander; Gào Xīn; Lloyd-Jones Donald M.; Kronenberg Florian; Correa Adolfo; Gieger Christian; Snieder Harold; Coresh Josef; Adeyemo Adebowale A.; Sedaghat Sanaz; Grove Megan L.; Lind Lars; Schwartz Joel; Ghasemi Sahar; Kühnel Brigitte; Meeks Karlijn A. C.; McCartney Daniel L.; Psaty Bruce M.; Zhao Wei; Ratliff Scott M.; Lorkowski Stefan; Marioni Riccardo E.; Schlosser Pascal; Hoppmann Anselm; van Meurs Joyce B. J.; Swenson Brenton R.; Reiner Alex P.; Ladd-Acosta Christine; Zheng Yinan; Nowak Christoph; Grundner-Culemann Franziska; Ekici Arif B.; Lehtimäki Terho; Agyemang Charles; Horvath Steve; Peters Annette; Ärnlöv Johan; Hurme Mikko A.; Eckardt Kai-Uwe; Hou Lifang; Akilesh Shreeram; Carmeli Cristian; Delgado Graciela E.; Sotoodehnia Nona; Prokisch Holger; Cox Simon R.; Joehanes Roby<p>Serum urate concentration can be studied in large datasets to find genetic and epigenetic loci that may be related to cardiometabolic traits. Here the authors identify and replicate 100 urate-associated CpGs, which ... -
Genetic loci and prioritization of genes for kidney function decline derived from a meta-analysis of 62 longitudinal genome-wide association studies
Waterworth Dawn M.; Rossing Peter; Carroll Robert J.; Sedaghat Sanaz; Sim Xueling; Tremblay Johanne; Sims Mario; Winkler Thomas W.; Lieb Wolfgang; Josyula Navya Shilpa; Lindgren Cecilia M.; Lukas Mary Ann; Chee Miao-Ling; Rosenkranz Alexander R.; Willer Cristen J.; Völker Uwe; White Harvey D.; Thio Chris H.L.; Böhnke Michael; Wallentin Lars; Nauck Matthias; Chai Jin-Fang; Köttgen Anna; Penninx Brenda W.J.H.; O’Donoghue Michelle L.; M.Raffield Laura; Parsa Afshin; Teumer Alexander; Ärnlöv Johan; Sabanayagam Charumathi; Kramer Holly; Nolte Ilja M.; Nutile Teresa; Kronenberg Florian; Hamet Pavel; Karabegović Irma; Wong Tien-Yin; Bottinger Erwin P.; Thomas Laurent F.; Vaccargiu Simona; Strauch Konstantin; Schmidt Reinhold; Ghanbari Mohsen; Bergler Tobias; Melander Olle; Brumpton Ben; Meitinger Thomas; Matias-Garcia Pamela R.; Waldenberger Melanie; Szymczak Silke; Psaty Bruce M.; Lange Leslie A.; Pirastu Mario; Endlich Karlhans; Freitag-Wolf Sandra; Bansal Nisha; Wuttke Matthias; Heid Iris M.; Lifelines Cohort Study; Cusi Daniele; Woodward Mark; Rotter Jerome I.; Rasheed Humaira; Stanzick Kira J.; Chalmers John; Preuss Michael H.; Tayo Bamidele O.; Hwang Shih-Jen; Degenhardt Frauke; Böger Carsten A.; Biggs Mary L.; Holm Hilma; Hishida Asahi; Feitosa Mary F.; Schulz Christina-Alexandra; Hoppmann Anselm; Bakker Stephan J.L.; Snieder Harold; Günther Felix; Biino Ginevra; Laakso Markku; Hutri-Kähönen Nina; Salvi Erika; Naito Mariko; Olafsson Isleifur; Lind Lars; Milaneschi Yuri; Loos Ruth J.F.; Mychaleckyj Josyf C.; Evans Michele K.; Ryan Kathleen A.; Sveinbjornsson Gardar; Thorsteinsdottir Unnur; Li Man; Li Yong; Kähönen Mika; Holleczek Bernd; Chaker Layal; Hofer Edith; Hveem Kristian; Gudbjartsson Daniel F.; Schöttker Ben; Lehtimäki Terho; Rice Kenneth M.; Gansevoort Ron T.; van der Harst Pim; Brenner Hermann; Lyytikäinen Leo-Pekka; Nikus Kjell; Yang Qiong; Shaffer Christian M.; Chee Miao-Li; Horn Katrin; Ciullo Marina; Giedraitis Vilmantas; Graham Sarah E.; Rheinberger Myriam; Wang Judy; van der Most Peter J.; Krämer Bernhard K.; Nakatochi Masahiro; Eckardt Kai-Uwe; Pattaro Cristian; Gorski Mathias; Cook James P.; Mononen Nina; Pendergrass Sarah A.; Scholz Markus; Ahluwalia Tarunveer S.; Yerges-Armstrong Laura M.; Wallner Stefan; Nalls Mike A.; Gieger Christian; Stark Klaus J.; Tin Adrienne; Cheng Ching-Yu; Stefansson Kari; Morris Andrew P.; O'Connell Jeffrey; Zonderman Alan B.; Verweij Niek; Hallan Stein; Coresh Josef; Koenig Wolfgang; Banas Bernhard; Ghasemi Sahar; Boerwinkle Eric; Åsvold Bjørn Olav; Nadkarni Girish N.; Stocker Hannah; Franke Andre; Jung Bettina; Zimmermann Martina; Mishra Pashupati P.; Ho Kevin; Ikram M. Arfan; Cocca Massimiliano; Kühnel Brigitte; Y.Chu Audrey; Ning Boting; Gampawar Piyush; de Borst Martin H.; Raitakari Olli T.; Sulem Patrick; Rizzi Federica; Meisinger Christa; Ruggiero Daniela; Khor Chiea-Chuen; Taylor Kent D.; Orho-Melander Marju; Mahajan Anubha; Schmidt Helena; Sieber Karsten B.; Fuchsberger Christian; Stringham Heather M.; Wakai Kenji; Kuusisto Johanna<p>Estimated glomerular filtration rate (eGFR) reflects kidney function. Progressive eGFR-decline can lead to kidney failure, necessitating dialysis or transplantation. Hundreds of loci from genome-wide association studies ... -
Meta-analyses identify DNA methylation associated with kidney function and damage
Bochud Murielle; Waldenberger Melanie; Fraszczyk Eliza; Ghasemi Sahar; Loh Marie; Teumer Alexander; Kasela Silva; Verweij Niek; Stringhini Silvia; Stocker Hanna R.; Peters Annette; Baccarelli Andrea; Adeyemo Adebowale A.; Walker Rosie M.; Lorkowski Stefan; Liu Dan; Wielscher Matthias; Sedaghat Sanaz; Zheng Yinan; Estonian Biobank Research Team; Genetics of DNA Methylation Consortium; Cox Simon R.; Nowak Christoph; Schöttker Ben; Gieger Christian; Lind Lars; Rosas Sylvia E.; Tin Adrienne; Winkelmann Juliane; Liu HongboB; Lehtimäki Terho; Franke Lude; Smith Jennifer A.; Aziz Nasir A.; Wolffenbuttel Bruce H. R.; Delgado Graciela E.; Kleber Marcus E.; Chambers John C.; Meeks Karlijn A. C.; Psaty Bruce M.; Levy Daniel; Nauck Matthias; März Winfried; McCartney Daniel L.; Marioni Riccardo E.; Hou Lifang; Joehanes Roby; Köttgen Anna; Raitakari Olli T.; Reiner Alex P.; Carmeli Cristian; Navas-Acien Ana; Jarvelin Marjo-Riitta; Fornage Myriam; Yu Zhi; Ratliff Scott M.; Hoppmann Anselm; Breteler Monique M. B.; Henneman Peter; Weihs Antoine; Sotoodehnia Nona; Schwartz Joel; Schlosser Pascal; Zhao Wei; Kühnel Brigitte; Hemani Gibran; Venema Andrea; Thio Chris H. L.; Mishra Pashupati P.; Ärnlöv Johan; Brenner Hermann; Evans Kathryn L.; Liu Yongmei; Agyemang Charles; Ekici Arif B.; Snieder Harold; Endlich Karlhans; Eckardt Kai-Uwe; Ghanbari Mohsen; Chaker Layal; Floyd James S.; Kronenberg Florian; Domingo-Relloso Arce; Kardia Sharon L. R.; van Vliet-Ostaptchouk Jana V.; Grundner-Culemann Franziska; Coresh Josef; Greenland Philip; Susztak Katalin; Herder Christian; Lohman Kurt; Horvath Steve; Harris Sarah E.; Lu Ake T.; Milani Lili; van Meurs Joyce B. J.; Kooner Jaspal S.; Lloyd-Jones Donald M.; Gao Xu; Corre Tanguy; Swenson Brenton R.; Kramer Holly; Hwang Shih-Jen; Cole Shelley A.; Prokisch Holger; Koenig Wolfgang; de Klein Niek; Gào Xīn; Min Josine L.; Correa Adolfo; Tellez-Plaza Maria; Sundström Johan; Matias-Garcia Pamela R.; Hurme Mikko A.; Grove Megan L.<p>Chronic kidney disease is a major public health burden. Elevated urinary albumin-to-creatinine ratio is a measure of kidney damage, and used to diagnose and stage chronic kidney disease. To extend the knowledge on ... -
The genomics of heart failure: design and rationale of the HERMES consortium
Bloom Heather L.; Lindgren Cecilia M.; Dunn Michael E.; Kuchenbaecker Karoline; Shah Sonia; Xing Heming; Ghanbari Mohsen; Engström Gunnar; Lumbers R. Thomas; Esko Tõnu; Torp-Pedersen Christian; Wang Xiaosong; White Harvey D.; de Denus Simon; Dehghan Abbas; Andersson Charlotte; Haggerty Christopher M.; Morley Michael P.; Lovering Ruth C.; Perreault Louis-Philippe Lemieux; Chaffin Mark D.; Weeke Peter E.; O'Donoghue Michelle L.; Morrison Alanna C.; Jacob Jaison; Owens Anjali T.; Asselin Geraldine; Carey David J.; Vaura F; Portilla-Fernandez Eliana; Nowak Christoph; Nelson Christopher P.; Ghasemi Sahar; Tardif Jean-Claude; Yang Yifan; Finan Chris; Magnusson Patrik; Sveinbjörnsson Garðar; Smith J. Gustav; Mälarstig Anders; Czuba Tomasz; Mann Douglas; Brown Michael R.; Stefansson Kari; Doney Alexander S.; Kamanu Frederick; Dudley Samuel C.; Fatemifar Ghazaleh; Giulianini Franco; Asselbergs Folkert W.; Holm Hilma; Romaine Simon P.R.; Fouodjio René; Voors Adriaan A.; Chen Xing; Yu Bing; Tuckwell Danny; Gottdiener John S.; Mordi Ify R.; Gutmann Rebecca; Felix Stephan B.; Kleber Marcus E.; Uitterlinden Andre G.; Melander Olle; Yerges-Armstrong Laura M.; Lotta Luca A.; Lin Honghuang; Helgadottir Anna; Salomaa Veikko; Hyde Craig L.; Ärnlöv Johan; Cleland John G.F.; Teder-Laving Maris; Chutkow William; Brunner-La Rocca Hans-Peter; Zhao Faye; Khaw Kay-Tee; Hemingway Harry; Ellinor Patrick T.; Teumer Alexander; Fougerousse Francoise; Chen Xu; Nagle Michael W.; Wiggins Kerri L.; Melloni Giorgio; Denaxas Spiros; Holmes Michael V.; Thorgeirsson Guðmundur; McMurray John J.V.; Taylor Kent D.; Hedman Åsa K.; Wareham Nicholas J.; Ruff Christian T.; Chasman Daniel I.; Stott David J.; Hillege Hans; Rotter Jerome I.; Psaty Bruce M.; März Winfried; Wilk Jemma B.; Yang Jian; Morris Andrew P.; Dubé Marie-Pierre; Cook James P.; Thorsteinsdottir Unnur; Weiss Raul; Shah Svati; Vasan Ramachandran S.; Lang Chim C.; Koekemoer Andrea; Kardys Isabella; van der Harst Pim; Chazara Olympe; Gui Hongsheng; Niiranen Teemu; Kraus Bill; Ford Ian; Sabatine Marc S.; Dörr Marcus; Völker Uwe; Delgado Graciela E.; Almgren Peter; Wells Quinn S.; Zannad Faiez; Salo Perttu; Lind Lars; Brandimarto Jeffrey; Giedraitis Vilmantas; Jukema J. Wouter; Gross Stefan; Chung Jonathan H.; Langenberg Claudia; Palmer Colin N.A.; Shalaby Alaa A.; Luan Jian’an; Perola Markus; Aragam Krishna G.; Stender Steen; Verweij Niek; Roselli Carolina; Cappola Thomas P.; Morris Andrew D.; Guðbjartsson Daníel F.; Trompet Stella; Hingorani Aroon D.; Mahajan Anubha; Newton-Cheh Christopher; Biggs Mary L.L; Swerdlow Daniel I.; Backman Joshua D.; Smith Nicholas L.; Marston Nicholas A.; Visscher Peter M.; Lubitz Steven A.; Rice Kenneth M.; Margulies Kenneth B.; Kavousi Maryam; Køber Lars; Niessner Alexander; Ridker Paul M.; Boersma Eric; Tyl Benoit; Samani Nilesh J.; Sattar Naveed; Lanfear David E.; Veluchamy Abirami; London Barry; Smelser Diane T.; van Setten Jessica; Tammesoo Mari-Liis; Sallah Neneh; Svensson Per; Paré Guillaume; Henry Albert<p><strong>Aims</strong> The HERMES (HEart failure Molecular Epidemiology for Therapeutic targets) consortium aims to identify the genomic and molecular basis of heart failure.</p><p><strong>Methods and results</strong> ...