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    • Genetic scores to stratify risk of developing multiple islet autoantibodies and type 1 diabetes: A prospective study in children 

      Åke Lernmark; Michael Laimighofer; Markus Hippich; Jorma Toppari; Anette-G. Ziegler; Kendra Vehik; Andrew T. Hattersley; Jeffrey P. Krischer; Jan Krumsiek; Beena Akolkar; William A. Hagopian; Jin-Xiong She; Michael N. Weedon; Brigitte I. Frohnert; Andrea K. Steck; Andreas Beyerlein; Christiane Winkler; Richard A. Oram; Marian J. Rewers; Stephen S. Rich; Ezio Bonifacio
      Background<br />Around 0.3% of newborns will develop autoimmunity to pancreatic beta cells in childhood and subsequently develop type 1 diabetes before adulthood. Primary prevention of type 1 diabetes will require early ...

    • Metabolite-related dietary patterns and the development of islet autoimmunity 

      Ulla Uusitalo; Randi K. Johnson; Oliver Fiehn; Jeffrey Krischer; Tessa Crume; Jin-Xiong She; Katerina Kechris; Åke Lernmark; Brian C . DeFelice; Beena Akolkar; Marci Sontag; Suvi M. Virtanen; Anette-G. Ziegler; Jorma Toppari; Jill M. Norris; & The TEDDY Study Group; Marian Rewers; Lauren Vanderlinden; William Hagopian; Andreas Beyerlein
      The role of diet in type 1 diabetes development is poorly understood. Metabolites, which reflect dietary response, may help elucidate this role. We explored metabolomics and lipidomics differences between 352 cases of islet ...