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Faecalibacterium prausnitzii Treatment Improves Hepatic Health and Reduces Adipose Tissue Inflammation in High-fat Fed Mice
<p>Faecalibacterium prausnitzii is considered as one of the most important bacterial indicators of a healthy gut. We studied the effects of oral F. prausnitzii treatment on high-fat fed mice. Compared to the high-fat control ...
Human milk metabolome is associated with symptoms of maternal psychological distress and milk cortisol
<p>The composition of human milk is subject to considerable
variation, but the effects of maternal stress are largely unknown. We
studied differences in human milk metabolome between Finnish mothers (n = 120,
secretors) with symptoms of prenatal symptoms of psychological distress
and milk cortisol concentrations. Human milk samples acquired at
2.5 months postpartum were analyzed using targeted <sup>1</sup>H NMR metabolomics.
Self-reported scores for depression (EPDS), overall anxiety (SCL-90),
and pregnancy-related anxiety (PRAQ) were used to evaluate psychological
distress. Prenatal psychological distress was positively associated
with concentrations of short-chain fatty acids, caprate, and
hypoxanthine (q < 0.0012). Milk cortisol was positively associated with lactate concentration (q < 0.05).
Changes in the human milk metabolome were shown to be associated with
maternal psychological distress and concentration of milk cortisol in a
dissimilarly, suggesting alterations in bacterial and energy metabolism
of the mother, respectively.</p>...
Effect of oat β-glucan of different molecular weights on fecal bile acids, urine metabolites and pressure in the digestive tract – A human cross over trial
<p>While the development of oat products often requires altered molecular weight (MW) of β-glucan, the resulting health implications are currently unclear. This 3-leg crossover trial (n = 14) investigated the effects of ...