Hae

Aineistot 1-7 / 7

Islet Autoimmunity and HLA Markers of Presymptomatic and Clinical Type 1 Diabetes: Joint Analyses of Prospective Cohort Studies in Finland, Germany, Sweden, and the US

Frohnert Brigitte I.; Veijola Riitta; Killian Michael B.; Ghalwash Mohamed; Toppari Jorma; Winkler Christiane; Jonsson Josefine; Ng Kenney; Ziegler Anette-Gabriele; Lundgren Markus; Hagopian William; Koski Eileen; Dunne Jessica L.; Knip Mikael; Anand Vibha; Rewers Marian; for the T1DI Study Group; Ilonen Jorma; Liu Bin; Li Ying

<div>OBJECTIVETo combine prospective cohort studies, by including HLA harmonization, and estimate risk of islet autoimmunity and progression to clinical diabetes. RESEARCH DESIGN AND METHODS For ...

Beta cell function in participants with single or multiple islet autoantibodies at baseline in the TEDDY Family Prevention Study: TEFA

Tossavainen Päivi; Martinez Maria Månsson; Katsarou Anastasia; Borg Henrik; Kero Jukka; Maziarz Marlena; Lernmark Åke; Törn Carina; The TEDDY Family (TEFA) Study Group; Veijola Riitta; Larsson Helena Elding; Koskenniemi Jaakko J.; Salami Falastin; Toppari Jorma; Lundgren Markus

AimThe aim of the present study was to assess beta cell function based on an oral glucose tolerance test (OGTT) in participants with single islet autoantibody or an intravenous glucose tolerance test (IvGTT) in ...

Imputing Longitudinal Growth Data in International Pediatric Studies: Does CDC Reference Suffice?

Frohnert Brigette I; Achenbach Peter; Anand Vibha; T1DI study group; Lundgren Markus; Veijola Riitta; Toppari Jorma; Li Zhingue

This study investigates a missing value imputation approach for longitudinal growth data in pediatric studies from multiple countries. We analyzed a combined cohort from five natural history studies of type 1 diabetes (T1D) ...

Factors Associated with Decline of C-peptide in a Cohort of Young Children Diagnosed with Type 1 Diabetes

Steck Andrea K; Rewers Marian J; Akolkar Beena; Hagopian William A; Toppari Jorma; Krischer Jeffrey P; Liu Xiang; Lundgren Markus; Haller Michael J; Ahmed Simi; Elding Larsson Helena; Veijola Riitta

Context: Understanding factors involved in the rate of C-peptide decline is needed to tailor therapies for type 1 diabetes (T1D).Objective: Evaluate factors associated with rate ...

Progression of type 1 diabetes from latency to symptomatic disease is predicted by distinct autoimmune trajectories

Hagopian William; Koski Eileen; Toppari Jorma; Dunne Jessica L; Lundgren Markus; Anand Vibha; Frohnert Brigitte I; the T1DI Study Group; Veijola Riitta; Achenbach Peter; Hu Jianying; Lernmark Åke; Ng Kenney; Kwon Bum Chul

Development of islet autoimmunity precedes the onset of type 1 diabetes in children, however, the presence of autoantibodies does not necessarily lead to manifest disease and the onset of clinical symptoms is hard to ...

HbA1c as a time predictive biomarker for an additional islet autoantibody and type 1 diabetes in seroconverted TEDDY children

You Lu; Akolkar Beena; Tamura Roy; Ziegler Anette-Gabriele; Rewers Marian; Lernmark Åke; Krischer Jeffrey; Salami Falastin; Larsson Helena Elding; Hagopian William; Toppari Jorma; Veijola Riitta; Lundgren Markus; Haller Michael J.; Törn Carina; TEDDY Study Group

Objective Increased level of glycated hemoglobin (HbA1c) is associated with type 1 diabetes onset that in turn is preceded by one to several autoantibodies against the pancreatic islet beta cell autoantigens; ...

Childhood Height Growth Rate Association With the Risk of Islet Autoimmunity and Development of Type 1 Diabetes

Li Zhiguo; Winkler Christiane; Anand Vibha; Hyöty Heikki; Maziarz Marlena; Lundgren Markus; Killian Michael B.; Koski Eileen; Waugh Kathleen; Veijola Riitta; Ng Kenney; Toppari Jorma; Martin Frank

ContextRapid growth has been suggested to promote islet autoimmunity and progression to type 1 diabetes (T1D). Childhood growth has not been analyzed separately from the infant growth period in most previous ...