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Respiratory virus type to guide predictive enrichment approaches in the management of the first episode of bronchiolitis: A systematic review
<p> It has become clear that severe bronchiolitis is a heterogeneous disease; even so, current bronchiolitis management guidelines rely on the one-size-fits-all approach regarding achieving both short-term and chronic ...
Childhood asthma outcomes during the COVID-19 pandemic: Findings from the PeARL multinational cohort
<p>Background <br></p><p>The interplay between COVID-19 pandemic and asthma in children is still unclear. We evaluated the impact of COVID-19 pandemic on childhood asthma outcomes.<br></p><p>Methods <br></p><p>The PeARL ...
The Role of Interferons in Driving Susceptibility to Asthma Following Bronchiolitis: Controversies and Research Gaps
<p>Bronchiolitis is the most common cause of hospitalization in infancy and is associated with a higher risk for the development of childhood asthma. However, not all children hospitalized with bronchiolitis will develop ...
Management of asthma in childhood: study protocol of a systematic evidence update by the Paediatric Asthma in Real Life (PeARL) Think Tank
<p>Introduction</p><p>Clinical recommendations for childhood asthma are often based on data extrapolated from studies conducted in adults, despite significant differences in mechanisms and response to treatments. The ...