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First-in-Human Study of 68 Ga-DOTA-Siglec-9, PET Ligand Targeting Vascular Adhesion Protein 1
Sialic acid-binding immunoglubulin-like lectin 9 (Siglec-9) is a ligand of vascular adhesion protein 1 (VAP-1). A gallium 68-labeled peptide of Siglec-9, <sup>68</sup>Ga-DOTA-Siglec-9, holds promise as a novel PET tracer ...
Seasonal variation in the brain μ-opioid receptor availability
<p>Seasonal rhythms influence emotion and sociability. The brain μ-opioid receptor (MOR) system modulates a multitude of seasonally varying socioemotional functions, but its seasonal variation remains elusive with no ...
Morbid obesity and type 2 diabetes alter intestinal fatty acid uptake and blood flow
<p>Aims: Bariatric surgery is the most effective treatment to tackle morbid obesity and type 2 diabetes, but the mechanisms of action are still unclear. The objective of this study was to investigate the effects of bariatric ...
68Ga-Citrate Positron Emission Tomography of Healthy Men: Whole-Body Biodistribution Kinetics and Radiation Dose Estimates
<p><sup>68</sup>Ga-citrate has one of the simplest chemical structures of all <sup>68</sup>Ga-radiopharmaceuticals, and its clinical use is justified by the proven medical applications using its isotope-labeled ...
Head-to-Head Comparison of 68Ga-Citrate and 18F-FDG PET/CT for Detection of Infectious Foci in Patients with Staphylococcus aureus Bacteraemia
<p>Purpose. This study evaluated the potential of <sup>68</sup>Ga-citrate positron emission tomography/computed tomography (PET/CT) for the detection of infectious foci in patients with Staphylococcus aureus bacteraemia by comparing it with 2-[<sup>18</sup>F]fluoro-2-deoxy--glucose (<sup>18</sup>F-FDG) PET/CT. Methods. Four patients admitted to hospital due to S. aureus bacteraemia underwent both <sup>18</sup>F-FDG and <sup>68</sup>Ga-citrate whole-body PET/CT scans to detect infectious foci. Results. The time from hospital admission and the initiation of antibiotic treatment to the first PET/CT was 4–10 days. The time interval between <sup>18</sup>F-FDG and <sup>68</sup>Ga-citrate PET/CT was 1–4 days. Three patients had vertebral osteomyelitis (spondylodiscitis) and one had osteomyelitis in the toe; these were detected by both <sup>18</sup>F-FDG (maximum standardised uptake value [SUV<sub>max</sub> 6.0 ± 1.0] ) and <sup>68</sup>Ga-citrate (SUV<sub>max</sub> 6.8 ± 3.5, P = 0.61). Three patients had soft tissue infectious foci, with more intense <sup>18</sup>F-FDG uptake (SUV<sub>max</sub> 6.5 ± 2.5) than <sup>68</sup>Ga-citrate uptake (SUV<sub>max</sub> 3.9 ± 1.2, P = 0.0033). Conclusions. Our small cohort of patients with S. aureus bacteraemia revealed that <sup>68</sup>Ga-citrate PET/CT is comparable to <sup>18</sup>F-FDG PET/CT for detection of osteomyelitis, whereas <sup>18</sup>F-FDG resulted in a higher signal for the detection of soft tissue infectious foci.</p>...
PET/CT to detect adverse reactions to metal debris in patients with metal-on-metal hip arthroplasty: an exploratory prospective study
Metal-on-metal (MoM) bearings in total hip arthroplasties and hip resurfacing arthroplasties have recently shown a new type of complication: adverse reactions to metal debris (ARMD). ARMD is characterized by local severe ...