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Correlation between 18F-1-amino-3-fluorocyclobutane-1-carboxylic acid (18F-fluciclovine) uptake and expression of alanine-serine-cysteine-transporter 2 (ASCT2) and L-type amino acid transporter 1 (LAT1) in primary prostate cancer
<p>Purpose: To evaluate the expression of alanine-serine-cysteine-transporter 2 (ASCT2) and L-type amino acid transporter1 (LAT1) in prostate cancer (PCa) and their impact on uptake of F-18-1-amino-3-fluorocyclobutane-1-carboxylic ...
Arthroscopic Bankart versus open Latarjet as a primary operative treatment for traumatic anteroinferior instability in young males: a randomised controlled trial with 2-year follow-up
<p><strong>Objectives: </strong>To compare the success rates of arthroscopic Bankart and open Latarjet procedure in the treatment of traumatic shoulder instability in young males.</p><p><strong>Design: </strong>Multicentre ...
Predicting the Need for Biopsy to Detect Clinically Significant Prostate Cancer in Patients with a Magnetic Resonance Imaging–detected Prostate Imaging Reporting and Data System/Likert ≥3 Lesion: Development and Multinational External Validation of the Imperial Rapid Access to Prostate Imaging and Diagnosis Risk Score
<p><strong>Background</strong>: Although multiparametric magnetic resonance imaging (MRI) has high<br>sensitivity, its lower specificity leads to a high prevalence of false-positive lesions requir-<br>ing biopsy.<br><str ...
Fiducial markers and their impact on ablation outcome for patients treated with MR-guided transurethral ablation (TULSA): a retrospective technical analysis
<p><strong>Objectives: </strong>Fiducial markers improve accuracy in external beam radiation therapy (EBRT) for treatment of prostate cancer (PCa). However, many patients recur after EBRT necessitating additional treatment, ...
Prospective comparison of 18F-PSMA-1007 PET/CT, whole-body MRI and CT in primary nodal staging of unfavourable intermediate- and high-risk prostate cancer
<div><b>Purpose</b> To prospectively compare F-18-prostate-specific membrane antigen (PSMA)-1007 positron emission tomography (PET)/CT, whole-body magnetic resonance imaging (WBMRI) including diffusion-weighted imaging ...
Brain free fatty acid uptake is elevated in morbid obesity, and is irreversible 6 months after bariatric surgery: A positron emission tomography study
<h3>Aim</h3><p>To investigate whether there are differences in brain fatty acid uptake (BFAU) between morbidly obese and lean subjects, and the effect of weight loss following bariatric surgery.</p><h3>Materials and ...
MRI texture analysis in differentiating luminal A and luminal B breast cancer molecular subtypes - a feasibility study
<h3>Conclusions</h3><p>Texture features which measure randomness, heterogeneity or smoothness and homogeneity may either directly or indirectly reflect underlying growth patterns of breast tumours. TA and volumetric analysis ...
Effects of meal and incretins in the regulation of splanchnic blood flow
Objective: Meal ingestion is followed by a redistribution of blood flow (BF) within the splanchnic region contributing to nutrient absorption, insulin secretion and glucose disposal, but factors regulating this phenomenon ...
Operative versus conservative treatment of small, nontraumatic supraspinatus tears in patients older than 55 years: over 5-year follow-up of a randomized controlled trial
<div><h3>Background</h3><p>Nontraumatic <a href="https://www.sciencedirect.com/topics/medicine-and-dentistry/rotator-cuff" title="Learn more about rotator cuff from ScienceDirect's AI-generated Topic Pages">rotator cuff</a> tear is a common shoulder problem that can be treated either conservatively or operatively. In the previous publications of the 1- and 2-year results of this trial, we found no significant between-group clinical differences. The aim of this study was to investigate the differences in mid-term clinical and radiologic outcomes in patients older than 55 years.</p></div><div><h3>Materials and methods</h3><p>One hundred eighty shoulders with symptomatic, nontraumatic supraspinatus tears were randomly assigned to 1 of the 3 cumulatively designed treatment groups: physiotherapy (group 1); <a href="https://www.sciencedirect.com/topics/medicine-and-dentistry/acromioplasty" title="Learn more about acromioplasty from ScienceDirect's AI-generated Topic Pages">acromioplasty</a> and physiotherapy (group 2); and rotator cuff repair, acromioplasty, and physiotherapy (group 3). The change in the Constant score was the primary outcome measure. The secondary outcome measures were the change in the <a href="https://www.sciencedirect.com/topics/medicine-and-dentistry/visual-analog-scale" title="Learn more about visual analog scale from ScienceDirect's AI-generated Topic Pages">visual analog scale</a> score for pain and patient satisfaction. Radiologic analysis included evaluation of glenohumeral <a href="https://www.sciencedirect.com/topics/medicine-and-dentistry/osteoarthritis" title="Learn more about osteoarthritis from ScienceDirect's AI-generated Topic Pages">osteoarthritis</a> (OA) and <a href="https://www.sciencedirect.com/topics/medicine-and-dentistry/rotator-cuff-rupture" title="Learn more about rotator cuff tear from ScienceDirect's AI-generated Topic Pages">rotator cuff tear</a> arthropathy (CTA).<br></p><div><div><div><h3>Results</h3><p>A total of 150 shoulders (mean age, 71 years) were available for analysis after a mean follow-up period of 6.2 years. The mean sagittal tear size of the supraspinatus tendon tear at baseline was 10 mm in all groups (P = .33). During follow-up, 8 shoulders in group 1 and 2 shoulders in group 2 crossed over to rotator cuff repair. The mean baseline Constant score was 57.1, 58.2, and 58.7 in groups 1, 2, and 3, respectively (P = .85). There were no significant differences (P = .84) in the mean change in the Constant score: 18.5 in group 1, 17.9 in group 2, and 20.0 in group 3. There were no statistically significant differences in the change in the visual analog scale pain score (P = .74) and patient satisfaction (P = .83). At follow-up, there were no statistically significant differences in the mean progression of glenohumeral OA (P = .538) or CTA (P = .485) among the groups. However, the mean progression of glenohumeral OA from baseline to follow-up was statistically significant in the trial population (P = .0045).</p></div><div><h3>Conclusions</h3><p>On the basis of this study, operative treatment is no better than conservative treatment regarding small, nontraumatic, single-tendon supraspinatus tears in patients older than 55 years. Operative treatment does not protect against degeneration of the glenohumeral joint or CTA. Conservative treatment is a reasonable option for the primary initial treatment of these tears.</p></div></div></div><div><div><h2>Level of evidence</h2><div>Level II</div><div>Randomized Controlled Trial</div><div>Treatment Study</div></div><div><h2>Keywords</h2><div>Rotator cuff tear</div><div>conservative treatment</div><div>rotator cuff repair</div><div>Constant score</div><div>VAS pain score</div><div>patient satisfaction</div><div>radiographic analysis</div><div>randomized controlled trial</div></div></div> </div>...